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Dr. Fares Hisham Subhi Al Ejeh

 https://orcid.org/0000-0002-1553-0077
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    20042025

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    • 2025

      EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation

      Offenhäuser, C., Dave, K. A., Beckett, K. J., Smith, F. M., Jayakody, B. A., Cooper, L. T., Agyei-Yeboah, H., McCarron, J. K., Li, Y., Bastick, K., Al-Ejeh, F., Cullen, J. K., Coulthard, M. G., Gorman, J. J., Boyd, A. W. & Day, B. W., 10 Feb 2025, In: Oncogene. 44, 4, p. 208-227 20 p., 107568.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Citation (Scopus)
    • 2023

      Cancer Incidence and Mortality Estimates in Arab Countries in 2018: A GLOBOCAN Data Analysis

      Al-Muftah, M. & Al-Ejeh, F., 1 Dec 2023, In: Cancer Epidemiology Biomarkers and Prevention. 32, 12, p. 1738-1746 9 p.

      Research output: Contribution to journal › Article › peer-review

      8 Citations (Scopus)
    • 2022

      Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

      Saunus, J. M., De Luca, X. M., Northwood, K., Raghavendra, A., Hasson, A., McCart Reed, A. E., Lim, M., Lal, S., Vargas, A. C., Kutasovic, J. R., Dalley, A. J., Miranda, M., Kalaw, E., Kalita-de Croft, P., Gresshoff, I., Al-Ejeh, F., Gee, J. M. W., Ormandy, C., Khanna, K. K. & Beesley, J. & 7 others, Chenevix-Trench, G., Green, A. R., Rakha, E. A., Ellis, I. O., Nicolau, D. V., Simpson, P. T. & Lakhani, S. R., Dec 2022, In: npj Breast Cancer. 8, 1, 57.

      Research output: Contribution to journal › Article › peer-review

      10 Citations (Scopus)

    • Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

      Al-Nesf, M. A. Y., Abdesselem, H. B., Bensmail, I., Ibrahim, S., Saeed, W. A. H., Mohammed, S. S. I., Razok, A., Alhussain, H., Aly, R. M. A., Al Maslamani, M., Ouararhni, K., Khatib, M. Y., Hssain, A. A., Omrani, A. S., Al-Kaabi, S., Al Khal, A., Al-Thani, A. A., Samsam, W., Farooq, A. & Al-Suwaidi, J. & 6 others, Al-Maadheed, M., Al-Siddiqi, H. H., Butler, A. E., Decock, J. V., Mohamed-Ali, V. & Al-Ejeh, F., Dec 2022, In: Nature Communications. 13, 1, 946.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      40 Citations (Scopus)
    • 2021

      G9a inhibition enhances checkpoint inhibitor blockade response in Melanoma

      Kelly, G. M., Al-Ejeh, F., McCuaig, R., Casciello, F., Kamal, N. A., Ferguson, B., Pritchard, A. L., Ali, S., Silva, I. P., Wilmott, J. S., Long, G. V., Scolyer, R. A., Rao, S., Hayward, N. K., Gannon, F. & Lee, J. S., 1 May 2021, In: Clinical Cancer Research. 27, 9, p. 2624-2635 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      28 Citations (Scopus)
    • 2020

      Clinicopathologic significance of nuclear HER4 and phospho-YAP(S127) in human breast cancers and matching brain metastases

      Kalita-de Croft, P., Lim, M., Chittoory, H., de Luca, X. M., Kutasovic, J. R., Day, B. W., Al-Ejeh, F., Simpson, P. T., McCart Reed, A. E., Lakhani, S. R. & Saunus, J. M., 2020, In: Therapeutic Advances in Medical Oncology. 12

      Research output: Contribution to journal › Article › peer-review

      Open Access
      9 Citations (Scopus)

    • Differential gene expression of tumor-infiltrating CD4+ T cells in advanced versus early stage colorectal cancer and identification of a gene signature of poor prognosis

      Sasidharan Nair, V., Saleh, R., Taha, R. Z., Toor, S. M., Murshed, K., Ahmed, A. A., Kurer, M. A., Abu Nada, M., Al Ejeh, F. & Elkord, E., 1 Jan 2020, In: OncoImmunology. 9, 1, 1825178.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      7 Citations (Scopus)

    • Differential gene expression of tumor-infiltrating CD8 + T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis

      Saleh, R., Sasidharan Nair, V., Toor, S. M., Taha, R. Z., Murshed, K., Al-Dhaheri, M., Khawar, M., Petkar, M. A., Abu Nada, M., Al-Ejeh, F. & Elkord, E., 18 Sept 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, e001294.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      24 Citations (Scopus)

    • G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome

      Casciello, F., Al-Ejeh, F., Miranda, M., Kelly, G., Baxter, E., Windloch, K., Gannon, F. & Lee, J. S., 2020, In: Theranostics. 10, 10, p. 4515-4529 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      30 Citations (Scopus)
    • 2019

      Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study

      Kutasovic, J. R., McCart Reed, A. E., Males, R., Sim, S., Saunus, J. M., Dalley, A., McEvoy, C. R., Dedina, L., Miller, G., Peyton, S., Reid, L., Lal, S., Niland, C., Ferguson, K., Fellowes, A. P., Al-Ejeh, F., Lakhani, S. R., Cummings, M. C. & Simpson, P. T., 1 Jan 2019, In: Journal of Pathology: Clinical Research. 5, 1, p. 25-39 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      34 Citations (Scopus)

    • Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

      EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators & BCFR Investigators, 1 Dec 2019, In: Nature Communications. 10, 1, 1741.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      86 Citations (Scopus)

    • Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells

      Genz, B., Coleman, M. A., Irvine, K. M., Kutasovic, J. R., Miranda, M., Gratte, F. D., Tirnitz-Parker, J. E. E., Olynyk, J. K., Calvopina, D. A., Weis, A., Cloonan, N., Robinson, H., Hill, M. M., Al-Ejeh, F. & Ramm, G. A., 1 Dec 2019, In: Scientific Reports. 9, 1, 8541.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      31 Citations (Scopus)

    • Proteomic analysis of the breast cancer brain metastasis microenvironment

      Kalita-de Croft, P., Straube, J., Lim, M., Al-Ejeh, F., Lakhani, S. R. & Saunus, J. M., 2 May 2019, In: International Journal of Molecular Sciences. 20, 10, 2524.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Citations (Scopus)

    • Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

      Wiegmans, A. P., Saunus, J. M., Ham, S., Lobb, R., Kutasovic, J. R., Dalley, A. J., Miranda, M., Atkinson, C., Foliaki, S. T., Ferguson, K., Niland, C., Johnstone, C. N., Lewis, V., Collins, S. J., Lakhani, S. R., Al-Ejeh, F. & Möller, A., 21 Mar 2019, In: JCI Insight. 4, 6, e124092.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      28 Citations (Scopus)
    • 2018

      A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

      Wu, L., Shi, W., Long, J., Guo, X., Michailidou, K., Beesley, J., Bolla, M. K., Shu, X. O., Lu, Y., Cai, Q., Al-Ejeh, F., Rozali, E., Wang, Q., Dennis, J., Li, B., Zeng, C., Feng, H., Gusev, A., Barfield, R. T. & Andrulis, I. L. & 190 others, Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Barrdahl, M., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Brauch, H., Brenner, H., Brinton, L., Broberg, P., Brucker, S. Y., Burwinkel, B., Caldés, T., Canzian, F., Carter, B. D., Castelao, J. E., Chang-Claude, J., Chen, X., Cheng, T. Y. D., Christiansen, H., Clarke, C. L., Collée, M., Cornelissen, S., Couch, F. J., Cox, D., Cox, A., Cross, S. S., Cunningham, J. M., Czene, K., Daly, M. B., Devilee, P., Doheny, K. F., Dörk, T., Dos-Santos-Silva, I., Dumont, M., Dwek, M., Eccles, D. M., Eilber, U., Eliassen, A. H., Engel, C., Eriksson, M., Fachal, L., Fasching, P. A., Figueroa, J., Flesch-Janys, D., Fletcher, O., Flyger, H., Fritschi, L., Gabrielson, M., Gago-Dominguez, M., Gapstur, S. M., García-Closas, M., Gaudet, M. M., Ghoussaini, M., Giles, G. G., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Guénel, P., Hahnen, E., Haiman, C. A., Håkansson, N., Hall, P., Hallberg, E., Hamann, U., Harrington, P., Hein, A., Hicks, B., Hillemanns, P., Hollestelle, A., Hoover, R. N., Hopper, J. L., Huang, G., Humphreys, K., Hunter, D. J., Jakubowska, A., Janni, W., John, E. M., Johnson, N., Jones, K., Jones, M. E., Jung, A., Kaaks, R., Kerin, M. J., Khusnutdinova, E., Kosma, V. M., Kristensen, V. N., Lambrechts, D., Le Marchand, L., Li, J., Lindström, S., Lissowska, J., Lo, W. Y., Loibl, S., Lubinski, J., Luccarini, C., Lux, M. P., MacInnis, R. J., Maishman, T., Kostovska, I. M., Mannermaa, A., Manson, J. A. E., Margolin, S., Mavroudis, D., Meijers-Heijboer, H., Meindl, A., Menon, U., Meyer, J., Mulligan, A. M., Neuhausen, S. L., Nevanlinna, H., Neven, P., Nielsen, S. F., Nordestgaard, B. G., Olopade, O. I., Olson, J. E., Olsson, H., Peterlongo, P., Peto, J., Plaseska-Karanfilska, D., Prentice, R., Presneau, N., Pylkäs, K., Rack, B., Radice, P., Rahman, N., Rennert, G., Rennert, H. S., Rhenius, V., Romero, A., Romm, J., Rudolph, A., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schmidt, M. K., Schmutzler, R. K., Schneeweiss, A., Scott, R. J., Scott, C. G., Seal, S., Shah, M., Shrubsole, M. J., Smeets, A., Southey, M. C., Spinelli, J. J., Stone, J., Surowy, H., Swerdlow, A. J., Tamimi, R. M., Tapper, W., Taylor, J. A., Terry, M. B., Tessier, D. C., Thomas, A., Thöne, K., Tollenaar, R. A. E. M., Torres, D., Truong, T., Untch, M., Vachon, C., Van Den Berg, D., Vincent, D., Waisfisz, Q., Weinberg, C. R., Wendt, C., Whittemore, A. S., Wildiers, H., Willett, W. C., Winqvist, R., Wolk, A., Xia, L., Yang, X. R., Ziogas, A., Ziv, E., Dunning, A. M., Pharoah, P. D. P., Simard, J., Milne, R. L., Edwards, S. L., Kraft, P., Easton, D. F., Chenevix-Trench, G. & Zheng, W., 1 Jul 2018, In: Nature Genetics. 50, 7, p. 968-978 11 p.

      Research output: Contribution to journal › Article › peer-review

      162 Citations (Scopus)

    • Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

      Johnson, J., Bessette, D. C., Saunus, J. M., Smart, C. E., Song, S., Johnston, R. L., Cocciardi, S., Rozali, E. N., Johnstone, C. N., Vargas, A. C., Kazakoff, S. H., BioBank, V. C., Khanna, K. K., Lakhani, S. R., Chenevix-Trench, G., Simpson, P. T., Nones, K., Waddell, N. & Al-Ejeh, F., 1 Jul 2018, In: Breast Cancer Research and Treatment. 170, 1, p. 179-188 10 p.

      Research output: Contribution to journal › Article › peer-review

      5 Citations (Scopus)

    • EphA3 pay-loaded antibody therapeutics for the treatment of glioblastoma

      Offenhäuser, C., Al-Ejeh, F., Puttick, S., Ensbey, K. S., Bruce, Z. C., Jamieson, P. R., Smith, F. M., Stringer, B. W., Carrington, B., Fuchs, A. V., Bell, C. A., Jeffree, R., Rose, S., Thurecht, K. J., Boyd, A. W. & Day, B. W., Dec 2018, In: Cancers. 10, 12, 519.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      32 Citations (Scopus)

    • Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

      Saunus, J. M., Smart, C. E., Kutasovic, J. R., Johnston, R. L., Kalita-de Croft, P., Miranda, M., Rozali, E. N., Vargas, A. C., Reid, L. E., Lorsy, E., Cocciardi, S., Seidens, T., McCart Reed, A. E., Dalley, A. J., Wockner, L. F., Johnson, J., Sarkar, D., Askarian-Amiri, M. E., Simpson, P. T. & Khanna, K. K. & 3 others, Chenevix-Trench, G., Al-Ejeh, F. & Lakhani, S. R., 1 Jan 2018, In: Breast Cancer Research and Treatment. 167, 1, p. 289-301 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      22 Citations (Scopus)
    • 2017

      EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

      Charmsaz, S., Al-Ejeh, F., Yeadon, T. M., Miller, K. J., Smith, F. M., Stringer, B. W., Moore, A. S., Lee, F. T., Cooper, L. T., Stylianou, C., Yarranton, G. T., Woronicz, J., Scott, A. M., Lackmann, M. & Boyd, A. W., 1 Aug 2017, In: Leukemia. 31, 8, p. 1779-1787 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      32 Citations (Scopus)

    • G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

      Casciello, F., Al-Ejeh, F., Kelly, G., Brennan, D. J., Ngiow, S. F., Young, A., Stoll, T., Windloch, K., Hill, M. M., Smyth, M. J., Gannon, F. & Lee, J. S., 3 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7077-7082 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      112 Citations (Scopus)

    • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

      Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Abctctb, I., Adams, M. & Adlard, J. & 461 others, Agata, S., Ahmed, S., Ahsan, H., Aittom, K. Ä., Fares, A. E., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. M., Azzollini, J., François, B., Balma, J. N., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Bernstein, L., Bignon, Y. J., Blazer, K. R., Blok, M. J., Blomqvist, C., Blot, W., Bobolis, K., Boeckx, B., Bogdanova, N. V., Bojesen, A., Bojesen, S. E., Bonanni, B., Anne-Lise, B. D., Bozsik, A., Bradbury, A. R., Brand, J. S., Brauch, H., Brenner, H., Brigitte, B. D. P., Brewer, C., Brinton, L., Broberg, P., Angela, B. W., Brunet, J., Brüning, T., Burwinkel, B., Buys, S. S., Byun, J., Cai, Q., Cald, T. É., Caligo, M. A., Campbell, I., Canzian, F., Caron, O., Carracedo, A., Carter, B. D., Esteban, C., Castera, L., Virginie, C. M., Chan, S. B., Jenny, C. C., Chanock, S. J., Chen, X., Cheng, T. Y. D., Chiquette, J., Christiansen, H., Claes, K. B., Clarke, C. L., Conner, T., Conroy, D. M., Cook, J., Cordina-Duverger, E., Cornelissen, S., Coupier, I., Cox, A., Cox, D. G., Cross, S. S., Cuk, K., Cunningham, J. M., Czene, K., Daly, M. B., Damiola, F., Darabi, H., Davidson, R., Leeneer, K. D. L., Devilee, P., Dicks, E., Diez, O., Ding, Y. C., Ditsch, N., Doheny, K. F., Domchek, S. M., Dorfling, C. M., Dörk, T., Dos-Santos-Silva, I., Dubois, S., Dugué, P. A., Dumont, M., Dunning, A. M., Durcan, L., Dwek, M., Dworniczak, B., Eccles, D., Eeles, R., Ehrencrona, H., Eilber, U., Ejlertsen, B., Ekici, A. B., Eliassen, A. H., Engel, C., Eriksson, M., Fachal, L., Faivre, L., Fasching, P. A., Faust, U., Figueroa, J., Flesch-Janys, D., Fletcher, O., Flyger, H., Foulkes, W. D., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Gaddam, P., Gammon, M. D., Ganz, P. A., Gapstur, S. M., Garber, J., Garcia-Barberan, V., Garciá-Saénz, J. A., Gaudet, M. M., Gauthier-Villars, M., Gehrig, A., Georgoulias, V., Gerdes, A. M., Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Goodfellow, P., Greene, M. H., Grenaker, G. A. I., Grip, M., Gronwald, J., Grundy, A., Gschwantler, D. K., Guénel, P., Guo, Q., Haeberle, L., Hahnen, E., Haiman, C. A., Håkansson, N., Hallberg, E., Hamann, U., Hamel, N., Hankinson, S., Hansen, T. V., Harrington, P., Hart, S. N., Hartikainen, J. M., Healey, C. S., Hein, A., Helbig, S., Henderson, A., Heyworth, J., Hicks, B., Hillemanns, P., Hodgson, S., Hogervorst, F. B., Hollestelle, A., Hooning, M. J., Hoover, B., Hopper, J. L., Hu, C., Huang, G., Hulick, P. J., Humphreys, K., Hunter, D. J., Imyanitov, E. N., Isaacs, C., Iwasaki, M., Izatt, L., Jakubowska, A., James, P., Janavicius, R., Janni, W., Jensen, U. B., John, E. M., Johnson, N., Jones, K., Jones, M., Jukkola-Vuorinen, A., Kaaks, R., Kabisch, M., Kaczmarek, K., Kang, D., Kast, K., Keeman, R., Kerin, M. J., Kets, C. M., Keupers, M. H., Khan, S., Khusnutdinova, E., Kiiski, J. I., Kim, S. W., Knight, J. A., Konstantopoulou, I., Kosma, V. M., Kristensen, V. N., Kruse, T. A., Kwong, A., Lænkholm, A. V., Laitman, Y., Lalloo, F., Lambrechts, D., Landsman, K., Lasset, C., Lazaro, C., Marchand, L. L., Al-Ejeh, F., Margreet, G. M. A., Bacot, F., Børresen-Dale, A. L., Bressac-De, B. P., Brooks-Wilson, A., Castelao, J. E., Caux-Moncoutier, V., Chang-Claude, J., McLaes, K. B., Dieter, F. J., Gschwantler-Kaulich, D., Lecarpentier, J., Lee, A., Lee, E., Won, J. L., Lee, M. H., Lejbkowicz, F., Lesueur, F., Li, J., Lilyquist, J., Lincoln, A., Lindblom, A., Lissowska, J., Lo, W. Y., Loibl, S., Long, J., Loud, J. T., Lubinski, J., Luccarini, C., Lush, M., MacInnis, R. J., Maishman, T., Makalic, E., Kostovska, I. M., Malone, K. E., Siranoush, M., Manson, J. E., Margolin, S., Martens, J. W., Martinez, M. E., Matsuo, K., Mavroudis, D., Mazoyer, S., McLean, C., Meijers-Heijboer, H., Menéndez, P., Meyer, J., Miao, H., Miller, N., Mitchell, G., Montagna, M., Muir, K., Mulligan, A. M., Mulot, C., Nadesan, S., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nevelsteen, I., Niederacher, D., Nielsen, S. F., Nordestgaard, B. G., Norman, A., Nussbaum, R. L., Olah, E., Olopade, O. I., Olson, J. E., Olswold, C., Ong, K. R., Oosterwijk, J. C., Orr, N., Osorio, A., Pankratz, V. S., Papi, L., Park-Simon, T. W., Paulsson-Karlsson, Y., Lloyd, R., Pedersen, I. S., Peissel, B., Peixoto, A., Perez, J. I., Peterlongo, P., Peto, J., Pfeiler, G., Phelan, C. M., Pinchev, M., Plaseska-Karanfilska, D., Poppe, B., Porteous, M. E., Prentice, R., Presneau, N., Prokofieva, D., Pugh, E., Pujana, M. A., Pylkäs, K., Rack, B., Radice, P., Rahman, N., Rantala, J., Rappaport-Fuerhauser, C., Rennert, G., Rennert, H. S., Rhenius, V., Rhiem, K., Richardson, A., Rodriguez, G. C., Romero, A., Romm, J., Rookus, M. A., Rudolph, A., Ruediger, T., Saloustros, E., Sanders, J., Sandler, D. P., Sangrajrang, S., Sawyer, E. J., Schmidt, D. F., Schoemaker, M. J., Schumacher, F., Schürmann, P., Schwentner, L., Scott, C., Scott, R. J., Seal, S., Senter, L., Seynaeve, C., Shah, M., Sharma, P., Shen, C. Y., Sheng, X., Shimelis, H., Shrubsole, M. J., Shu, X. O., Side, L. E., Singer, C. F., Sohn, C., Southey, M. C., Spinelli, J. J., Spurdle, A. B., Stegmaier, C., Stoppa-Lyonnet, D., Sukiennicki, G., Surowy, H., Sutter, C., Swerdlow, A., Szabo, C. I., Tamimi, R. M., Tan, Y. Y., Taylor, J. A., Tejada, M. I., Tengström, M., Teo, S. H., Terry, M. B., Tessier, D. C., Teul, A. E., Thöne, K., Thull, D. L., Tibiletti, M. G., Tihomirova, L., Tischkowitz, M., Toland, A. E., Tollenaar, R. A. M., Tomlinson, I., Tong, L., Torres, D., Tranchant, M., Truong, T., Tucker, K., Tung, N., Tyrer, J., Ulmer, H. U., Vachon, C., Christi, V. A. J., Den Berg, D. V., Ouweland, A. M. V., Van Rensburg, E. J., Varesco, L., Varon-Mateeva, R., Vega, A., Viel, A., Vijai, J., Vincent, D., Vollenweider, J., Walker, L., Wang, Z., Wang-Gohrke, S., Wappenschmidt, B., Weinberg, C. R., Weitzel, J. N., Wendt, C., Wesseling, J., Whittemore, A. S., Wijnen, J. T., Willett, W., Winqvist, R., Wolk, A., Wu, A. H., Xia, L., Yang, X. R., Yannoukakos, D., Zaffaroni, D., Zheng, W., Zhu, B., Ziogas, A., Ziv, E., Zorn, K. K., Gago-Dominguez, M., Mannermaa, A., Olsson, H., Teixeira, M. R., Stone, J., Offit, K., Ottini, L., Park, S. K., Thomassen, M., Hall, P., Meindl, A., Schmutzler, R. K., Droit, A., Bader, G. D., Pharoah, P. D., Couch, F. J., Easton, D. F., Kraft, P., Chenevix-Trench, G., Garciá-Closas, M., Antoniou, A. C. & Simard, J., 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1767-1778 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      292 Citations (Scopus)

    • Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage

      Betts, J. A., Moradi Marjaneh, M., Al-Ejeh, F., Lim, Y. C., Shi, W., Sivakumaran, H., Tropée, R., Patch, A. M., Clark, M. B., Bartonicek, N., Wiegmans, A. P., Hillman, K. M., Kaufmann, S., Bain, A. L., Gloss, B. S., Crawford, J., Kazakoff, S., Wani, S., Wen, S. W. & Day, B. & 11 others, Möller, A., Cloonan, N., Pearson, J., Brown, M. A., Mercer, T. R., Waddell, N., Khanna, K. K., Dray, E., Dinger, M. E., Edwards, S. L. & French, J. D., 3 Aug 2017, In: American Journal of Human Genetics. 101, 2, p. 255-266 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      74 Citations (Scopus)

    • MITF and BRN2 contribute to metastatic growth after dissemination of melanoma

      Simmons, J. L., Pierce, C. J., Al-Ejeh, F. & Boyle, G. M., 1 Dec 2017, In: Scientific Reports. 7, 1, 10909.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      48 Citations (Scopus)

    • Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

      Ward, A., Dong, L., Harris, J. M., Khanna, K. K., Al-Ejeh, F., Fairlie, D. P., Wiegmans, A. P. & Liu, L., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3096-3100 5 p.

      Research output: Contribution to journal › Article › peer-review

      18 Citations (Scopus)

    • Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

      Shi, W., Vu, T., Boucher, D., Biernacka, A., Nde, J., Pandita, R. K., Straube, J., Boyle, G. M., Al-Ejeh, F., Nag, P., Jeffery, J., Harris, J. L., Bain, A. L., Grzelak, M., Skrzypczak, M., Mitra, A., Dojer, N., Crosetto, N., Cloonan, N. & Becherel, O. J. & 8 others, Finnie, J., Skaar, J. R., Walkley, C. R., Pandita, T. K., Rowicka, M., Ginalski, K., Lane, S. W. & Khanna, K. K., 4 May 2017, In: Blood. 129, 18, p. 2471-2478 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      19 Citations (Scopus)
    • 2016

      Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer

      Milevskiy, M. J. G., Al-Ejeh, F., Saunus, J. M., Northwood, K. S., Bailey, P. J., Betts, J. A., Reed, A. E. M. C., Nephew, K. P., Stone, A., Gee, J. M. W., Dowhan, D. H., Dray, E., Shewan, A. M., French, J. D., Edwards, S. L., Clark, S. J., Lakhani, S. R. & Brown, M. A., 1 Aug 2016, In: Human Molecular Genetics. 25, 15, p. 3269-3283 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      62 Citations (Scopus)

    • RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy

      Wiegmans, A. P., Miranda, M., Wen, S. W., Al-Ejeh, F. & Möller, A., 2016, In: Oncotarget. 7, 37, p. 60087-60100 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      23 Citations (Scopus)
    • 2015

      EphA2 is a therapy target in EphA2-positive leukemias but is not essential for normal hematopoiesis or leukemia

      Charmsaz, S., Beckett, K., Smith, F. M., Bruedigam, C., Moore, A. S., Al-Ejeh, F., Lane, S. W. & Boyd, A. W., 17 Jun 2015, In: PLoS ONE. 10, 6, e0130692.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      22 Citations (Scopus)

    • Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

      Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Nones, K., McCart Reed, A. E., Miller, D., Wilson, P. J., Al-Ejeh, F., Mariasegaram, M., Lau, Q., Withers, T., Jeffree, R. L., Reid, L. E., Da Silva, L., Matsika, A., Niland, C. M., Cummings, M. C. & Bruxner, T. J. C. & 32 others, Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E., Wani, S., Anderson, M. J., Fink, J. L., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Taylor, D., Waddell, N., Wood, S., Xu, Q., Kassahn, K. S., Narayanan, V., Taib, N. A., Teo, S. H., Chow, Y. P., Kconfa, B., Jat, P. S., Brandner, S., Flanagan, A. M., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. & Lakhani, S. R., Nov 2015, In: Journal of Pathology. 237, 3, p. 363-378 16 p.

      Research output: Contribution to journal › Article › peer-review

      103 Citations (Scopus)

    • MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments

      Miranda, M., Rozali, E., Khanna, K. K. & Al-Ejeh, F., 2015, In: Oncoscience. 2, 2, p. 99-101 3 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      25 Citations (Scopus)

    • Using the MCF10A/MCF10CA1a breast cancer progression cell line model to investigate the effect of active, mutant forms of EGFR in breast cancer development and treatment using gefitinib

      Bessette, D. C., Tilch, E., Seidens, T., Quinn, M. C. J., Wiegmans, A. P., Shi, W., Cocciardi, S., McCart-Reed, A., Saunus, J. M., Simpson, P. T., Grimmond, S. M., Lakhani, S. R., Khanna, K. K., Waddell, N., Al-Ejeh, F. & Chenevix-Trench, G., 13 May 2015, In: PLoS ONE. 10, 5, e0125232.

      Research output: Contribution to journal › Article › peer-review

      24 Citations (Scopus)
    • 2014

      Eph family co-expression patterns define unique clusters predictive of cancer phenotype

      Al-Ejeh, F., Offenhäuser, C., Lim, Y. C., Stringer, B. W., Day, B. W. & Boyd, A. W., 1 Dec 2014, In: Growth Factors. 32, 6, p. 254-264 11 p.

      Research output: Contribution to journal › Article › peer-review

      8 Citations (Scopus)

    • Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

      Al-Ejeh, F., Pajic, M., Shi, W., Kalimutho, M., Miranda, M., Nagrial, A. M., Chou, A., Biankin, A. V., Grimmond, S. M., Brown, M. P. & Khanna, K. K., 15 Jun 2014, In: Clinical Cancer Research. 20, 12, p. 3187-3197 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      37 Citations (Scopus)

    • Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

      Al-Ejeh, F., Miranda, M., Shi, W., Simpson, P. T., Song, S., Vargas, A. C., Saunus, J. M., Smart, C. E., Mariasegaram, M., Wiegmans, A. P., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 2014, In: Oncotarget. 5, 10, p. 3145-3158 14 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      40 Citations (Scopus)

    • Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

      Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 1 Jan 2014, In: Oncogenesis. 3, 4, e100.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      65 Citations (Scopus)

    • Postchemotherapy and tumor-selective targeting with the la-specific DAB4 monoclonal antibody relates to apoptotic cell clearance

      Al-Ejeh, F., Staudacher, A. H., Smyth, D. R., Darby, J. M., Denoyer, D., Tsopelas, C., Hicks, R. J. & Brown, M. P., 1 May 2014, In: Journal of Nuclear Medicine. 55, 5, p. 772-779 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      16 Citations (Scopus)

    • Rad51 supports triple negative breast cancer metastasis

      Wiegmans, A. P., Al-Ejeh, F., Chee, N., Yap, P. Y., Gorski, J. J., Da Silva, L., Bolderson, E., Chenevix-Trench, G., Anderson, R., Simpson, P. T., Lakhani, S. R. & Khanna, K. K., 2014, In: Oncotarget. 5, 10, p. 3261-3272 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      81 Citations (Scopus)

    • SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent Re-replication

      Johansson, P., Jeffery, J., Al-Ejeh, F., Schulz, R. B., Callen, D. F., Kumar, R. & Khanna, K. K., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18514-18525 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      48 Citations (Scopus)

    • The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the la-specific antibody APOMAB®

      Staudacher, A. H., Al-Ejeh, F., Fraser, C. K., Darby, J. M., Roder, D. M., Ruszkiewicz, A., Manavis, J. & Brown, M. P., 2014, In: EJNMMI Research. 4, 1, p. 1-13 13 p., 2.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      23 Citations (Scopus)
    • 2013

      EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

      Day, B. W., Stringer, B. W., Al-Ejeh, F., Ting, M. J., Wilson, J., Ensbey, K. S., Jamieson, P. R., Bruce, Z. C., Lim, Y. C., Offenhäuser, C., Charmsaz, S., Cooper, L. T., Ellacott, J. K., Harding, A., Leveque, L., Inglis, P., Allan, S., Walker, D. G., Lackmann, M. & Osborne, G. & 4 others, Khanna, K. K., Reynolds, B. A., Lickliter, J. D. & Boyd, A. W., 11 Feb 2013, In: Cancer Cell. 23, 2, p. 238-248 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      186 Citations (Scopus)

    • Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2

      Shi, W., Bain, A. L., Schwer, B., Al-Ejeh, F., Smith, C., Wong, L., Chai, H., Miranda, M. S., Ho, U., Kawaguchi, M., Miura, Y., Finnie, J. W., Wall, M., Heierhorst, J., Wicking, C., Spring, K. J., Alt, F. W. & Khanna, K. K., Feb 2013, In: PLoS Genetics. 9, 2, e1003298.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      26 Citations (Scopus)

    • Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

      Al-Ejeh, F., Shi, W., Miranda, M., Simpson, P. T., Vargas, A. C., Song, S., Wiegmans, A. P., Swarbrick, A., Welm, A. L., Brown, M. P., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 1 Jun 2013, In: Journal of Nuclear Medicine. 54, 6, p. 913-921 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      66 Citations (Scopus)
    • 2012

      Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

      Noll, J. E., Jeffery, J., Al-Ejeh, F., Kumar, R., Khanna, K. K., Callen, D. F. & Neilsen, P. M., 7 Jun 2012, In: Oncogene. 31, 23, p. 2836-2848 13 p.

      Research output: Contribution to journal › Article › peer-review

      60 Citations (Scopus)

    • Tocotrienol as a potential anticancer agent

      Ling, M. T., Luk, S. U., Al-Ejeh, F. & Khanna, K. K., 1 Feb 2012, In: Carcinogenesis. 33, 2, p. 233-239 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      84 Citations (Scopus)
    • 2011

      Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges

      Simpson, P. T., Vargas, A. C., Al-Ejeh, F., Khanna, K. K., Chenevix-Trench, G. & Lakhani, S. R., Feb 2011, In: Human Pathology. 42, 2, p. 153-165 13 p.

      Research output: Contribution to journal › Article › peer-review

      4 Citations (Scopus)

    • Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

      Neilsen, P. M., Noll, J. E., Suetani, R. J., Schulz, R. B., Al-Ejeh, F., Evdokiou, A., Lane, D. P. & Callen, D. F., Dec 2011, In: Oncotarget. 2, 12, p. 1203-1217 15 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      101 Citations (Scopus)

    • Nutlin-3a is a potential therapeutic for Ewing sarcoma

      Pishas, K. I., Al-Ejeh, F., Zinonos, I., Kumar, R., Evdokiou, A., Brown, M. P., Callen, D. F. & Neilsen, P. M., 1 Feb 2011, In: Clinical Cancer Research. 17, 3, p. 494-504 11 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      60 Citations (Scopus)

    • Plasma functionalized PDMS microfluidic chips: Towards point-of-care capture of circulating tumor cells

      Kurkuri, M. D., Al-Ejeh, F., Shi, J. Y., Palms, D., Prestidge, C., Griesser, H. J., Brown, M. P. & Thierry, B., 28 Jun 2011, In: Journal of Materials Chemistry. 21, 24, p. 8841-8848 8 p.

      Research output: Contribution to journal › Article › peer-review

      35 Citations (Scopus)
    • 2009

      APOMAB®, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

      Al-Ejeh, F., Darby, J. M., Tsopelas, C., Smyth, D., Manavis, J. & Brown, M. P., 27 Feb 2009, In: PLoS ONE. 4, 2, e4558.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      32 Citations (Scopus)

    • A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

      Al-Ejeh, F., Darby, J. M., Thierry, B. & Brown, M. P., May 2009, In: Nuclear Medicine and Biology. 36, 4, p. 395-402 8 p.

      Research output: Contribution to journal › Article › peer-review

      37 Citations (Scopus)
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