Fares Hisham Subhi Al Ejeh

2024

EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation

Offenhäuser, C., Dave, K. A., Beckett, K. J., Smith, F. M., Jayakody, B. A., Cooper, L. T., Agyei-Yeboah, H., McCarron, J. K., Li, Y., Bastick, K., Al-Ejeh, F., Cullen, J. K., Coulthard, M. G., Gorman, J. J., Boyd, A. W. & Day, B. W., 7 Nov 2024, In: Oncogene. 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Cancer Incidence and Mortality Estimates in Arab Countries in 2018: A GLOBOCAN Data Analysis

Al-Muftah, M. & Al-Ejeh, F., 1 Dec 2023, In: Cancer Epidemiology Biomarkers and Prevention. 32, 12, p. 1738-1746 9 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2022

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Saunus, J. M., De Luca, X. M., Northwood, K., Raghavendra, A., Hasson, A., McCart Reed, A. E., Lim, M., Lal, S., Vargas, A. C., Kutasovic, J. R., Dalley, A. J., Miranda, M., Kalaw, E., Kalita-de Croft, P., Gresshoff, I., Al-Ejeh, F., Gee, J. M. W., Ormandy, C., Khanna, K. K. & Beesley, J. & 7 others, Chenevix-Trench, G., Green, A. R., Rakha, E. A., Ellis, I. O., Nicolau, D. V., Simpson, P. T. & Lakhani, S. R., 2 May 2022, In: npj Breast Cancer. 8, 1, 16 p., 57.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

Al-Nesf, M. A. Y., Abdesselem, H. B., Bensmail, I., Ibrahim, S., Saeed, W. A. H., Mohammed, S. S. I., Razok, A., Alhussain, H., Aly, R. M. A., Al Maslamani, M., Ouararhni, K., Khatib, M. Y., Hssain, A. A., Omrani, A. S., Al-Kaabi, S., Al Khal, A., Al-Thani, A. A., Samsam, W., Farooq, A. & Al-Suwaidi, J. & 6 others, Al-Maadheed, M., Al-Siddiqi, H. H., Butler, A. E., Decock, J. V., Mohamed-Ali, V. & Al-Ejeh, F., 17 Feb 2022, In: Nature Communications. 13, 1, 14 p., 946.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

2021

G9a inhibition enhances checkpoint inhibitor blockade response in Melanoma

Kelly, G. M., Al-Ejeh, F., McCuaig, R., Casciello, F., Kamal, N. A., Ferguson, B., Pritchard, A. L., Ali, S., Silva, I. P., Wilmott, J. S., Long, G. V., Scolyer, R. A., Rao, S., Hayward, N. K., Gannon, F. & Lee, J. S., 1 May 2021, In: Clinical Cancer Research. 27, 9, p. 2624-2635 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

2020

Clinicopathologic significance of nuclear HER4 and phospho-YAP(S¹²⁷) in human breast cancers and matching brain metastases

Kalita-de Croft, P., Lim, M., Chittoory, H., de Luca, X. M., Kutasovic, J. R., Day, B. W., Al-Ejeh, F., Simpson, P. T., McCart Reed, A. E., Lakhani, S. R. & Saunus, J. M., 2020, In: Therapeutic Advances in Medical Oncology. 12

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Differential gene expression of tumor-infiltrating CD4⁺ T cells in advanced versus early stage colorectal cancer and identification of a gene signature of poor prognosis

Sasidharan Nair, V., Saleh, R., Taha, R. Z., Toor, S. M., Murshed, K., Ahmed, A. A., Kurer, M. A., Abu Nada, M., Al Ejeh, F. & Elkord, E., 1 Jan 2020, In: OncoImmunology. 9, 1, 1825178.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Differential gene expression of tumor-infiltrating CD8 + T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis

Saleh, R., Sasidharan Nair, V., Toor, S. M., Taha, R. Z., Murshed, K., Al-Dhaheri, M., Khawar, M., Petkar, M. A., Abu Nada, M., Al-Ejeh, F. & Elkord, E., 18 Sept 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, e001294.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome

Casciello, F., Al-Ejeh, F., Miranda, M., Kelly, G., Baxter, E., Windloch, K., Gannon, F. & Lee, J. S., 2020, In: Theranostics. 10, 10, p. 4515-4529 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

2019

Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study

Kutasovic, J. R., McCart Reed, A. E., Males, R., Sim, S., Saunus, J. M., Dalley, A., McEvoy, C. R., Dedina, L., Miller, G., Peyton, S., Reid, L., Lal, S., Niland, C., Ferguson, K., Fellowes, A. P., Al-Ejeh, F., Lakhani, S. R., Cummings, M. C. & Simpson, P. T., 1 Jan 2019, In: Journal of Pathology: Clinical Research. 5, 1, p. 25-39 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

EMBRACE Collaborators, GC-HBOC Study Collaborators, GEMO Study Collaborators, ABCTB Investigators, HEBON Investigators & BCFR Investigators, 1 Dec 2019, In: Nature Communications. 10, 1, 1741.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Citations (Scopus)

Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells

Genz, B., Coleman, M. A., Irvine, K. M., Kutasovic, J. R., Miranda, M., Gratte, F. D., Tirnitz-Parker, J. E. E., Olynyk, J. K., Calvopina, D. A., Weis, A., Cloonan, N., Robinson, H., Hill, M. M., Al-Ejeh, F. & Ramm, G. A., 1 Dec 2019, In: Scientific Reports. 9, 1, 8541.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

Proteomic analysis of the breast cancer brain metastasis microenvironment

Kalita-de Croft, P., Straube, J., Lim, M., Al-Ejeh, F., Lakhani, S. R. & Saunus, J. M., 2 May 2019, In: International Journal of Molecular Sciences. 20, 10, 2524.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Wiegmans, A. P., Saunus, J. M., Ham, S., Lobb, R., Kutasovic, J. R., Dalley, A. J., Miranda, M., Atkinson, C., Foliaki, S. T., Ferguson, K., Niland, C., Johnstone, C. N., Lewis, V., Collins, S. J., Lakhani, S. R., Al-Ejeh, F. & Möller, A., 21 Mar 2019, In: JCI Insight. 4, 6, e124092.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

2018

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Wu, L., Shi, W., Long, J., Guo, X., Michailidou, K., Beesley, J., Bolla, M. K., Shu, X. O., Lu, Y., Cai, Q., Al-Ejeh, F., Rozali, E., Wang, Q., Dennis, J., Li, B., Zeng, C., Feng, H., Gusev, A., Barfield, R. T. & Andrulis, I. L. & 190 others, Anton-Culver, H., Arndt, V., Aronson, K. J., Auer, P. L., Barrdahl, M., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Blomqvist, C., Bogdanova, N. V., Bojesen, S. E., Brauch, H., Brenner, H., Brinton, L., Broberg, P., Brucker, S. Y., Burwinkel, B., Caldés, T., Canzian, F., Carter, B. D., Castelao, J. E., Chang-Claude, J., Chen, X., Cheng, T. Y. D., Christiansen, H., Clarke, C. L., Collée, M., Cornelissen, S., Couch, F. J., Cox, D., Cox, A., Cross, S. S., Cunningham, J. M., Czene, K., Daly, M. B., Devilee, P., Doheny, K. F., Dörk, T., Dos-Santos-Silva, I., Dumont, M., Dwek, M., Eccles, D. M., Eilber, U., Eliassen, A. H., Engel, C., Eriksson, M., Fachal, L., Fasching, P. A., Figueroa, J., Flesch-Janys, D., Fletcher, O., Flyger, H., Fritschi, L., Gabrielson, M., Gago-Dominguez, M., Gapstur, S. M., García-Closas, M., Gaudet, M. M., Ghoussaini, M., Giles, G. G., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Guénel, P., Hahnen, E., Haiman, C. A., Håkansson, N., Hall, P., Hallberg, E., Hamann, U., Harrington, P., Hein, A., Hicks, B., Hillemanns, P., Hollestelle, A., Hoover, R. N., Hopper, J. L., Huang, G., Humphreys, K., Hunter, D. J., Jakubowska, A., Janni, W., John, E. M., Johnson, N., Jones, K., Jones, M. E., Jung, A., Kaaks, R., Kerin, M. J., Khusnutdinova, E., Kosma, V. M., Kristensen, V. N., Lambrechts, D., Le Marchand, L., Li, J., Lindström, S., Lissowska, J., Lo, W. Y., Loibl, S., Lubinski, J., Luccarini, C., Lux, M. P., MacInnis, R. J., Maishman, T., Kostovska, I. M., Mannermaa, A., Manson, J. A. E., Margolin, S., Mavroudis, D., Meijers-Heijboer, H., Meindl, A., Menon, U., Meyer, J., Mulligan, A. M., Neuhausen, S. L., Nevanlinna, H., Neven, P., Nielsen, S. F., Nordestgaard, B. G., Olopade, O. I., Olson, J. E., Olsson, H., Peterlongo, P., Peto, J., Plaseska-Karanfilska, D., Prentice, R., Presneau, N., Pylkäs, K., Rack, B., Radice, P., Rahman, N., Rennert, G., Rennert, H. S., Rhenius, V., Romero, A., Romm, J., Rudolph, A., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schmidt, M. K., Schmutzler, R. K., Schneeweiss, A., Scott, R. J., Scott, C. G., Seal, S., Shah, M., Shrubsole, M. J., Smeets, A., Southey, M. C., Spinelli, J. J., Stone, J., Surowy, H., Swerdlow, A. J., Tamimi, R. M., Tapper, W., Taylor, J. A., Terry, M. B., Tessier, D. C., Thomas, A., Thöne, K., Tollenaar, R. A. E. M., Torres, D., Truong, T., Untch, M., Vachon, C., Van Den Berg, D., Vincent, D., Waisfisz, Q., Weinberg, C. R., Wendt, C., Whittemore, A. S., Wildiers, H., Willett, W. C., Winqvist, R., Wolk, A., Xia, L., Yang, X. R., Ziogas, A., Ziv, E., Dunning, A. M., Pharoah, P. D. P., Simard, J., Milne, R. L., Edwards, S. L., Kraft, P., Easton, D. F., Chenevix-Trench, G. & Zheng, W., 1 Jul 2018, In: Nature Genetics. 50, 7, p. 968-978 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

153 Citations (Scopus)

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

Johnson, J., Bessette, D. C., Saunus, J. M., Smart, C. E., Song, S., Johnston, R. L., Cocciardi, S., Rozali, E. N., Johnstone, C. N., Vargas, A. C., Kazakoff, S. H., BioBank, V. C., Khanna, K. K., Lakhani, S. R., Chenevix-Trench, G., Simpson, P. T., Nones, K., Waddell, N. & Al-Ejeh, F., 1 Jul 2018, In: Breast Cancer Research and Treatment. 170, 1, p. 179-188 10 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

EphA3 pay-loaded antibody therapeutics for the treatment of glioblastoma

Offenhäuser, C., Al-Ejeh, F., Puttick, S., Ensbey, K. S., Bruce, Z. C., Jamieson, P. R., Smith, F. M., Stringer, B. W., Carrington, B., Fuchs, A. V., Bell, C. A., Jeffree, R., Rose, S., Thurecht, K. J., Boyd, A. W. & Day, B. W., Dec 2018, In: Cancers. 10, 12, 519.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Saunus, J. M., Smart, C. E., Kutasovic, J. R., Johnston, R. L., Kalita-de Croft, P., Miranda, M., Rozali, E. N., Vargas, A. C., Reid, L. E., Lorsy, E., Cocciardi, S., Seidens, T., McCart Reed, A. E., Dalley, A. J., Wockner, L. F., Johnson, J., Sarkar, D., Askarian-Amiri, M. E., Simpson, P. T. & Khanna, K. K. & 3 others, Chenevix-Trench, G., Al-Ejeh, F. & Lakhani, S. R., 1 Jan 2018, In: Breast Cancer Research and Treatment. 167, 1, p. 289-301 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

2017

EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

Charmsaz, S., Al-Ejeh, F., Yeadon, T. M., Miller, K. J., Smith, F. M., Stringer, B. W., Moore, A. S., Lee, F. T., Cooper, L. T., Stylianou, C., Yarranton, G. T., Woronicz, J., Scott, A. M., Lackmann, M. & Boyd, A. W., 1 Aug 2017, In: Leukemia. 31, 8, p. 1779-1787 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

Casciello, F., Al-Ejeh, F., Kelly, G., Brennan, D. J., Ngiow, S. F., Young, A., Stoll, T., Windloch, K., Hill, M. M., Smyth, M. J., Gannon, F. & Lee, J. S., 3 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7077-7082 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Citations (Scopus)

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., Lemaçon, A., Soucy, P., Dennis, J., Jiang, X., Rostamianfar, A., Finucane, H., Bolla, M. K., McGuffog, L., Wang, Q., Aalfs, C. M., Abctctb, I., Adams, M. & Adlard, J. & 461 others, Agata, S., Ahmed, S., Ahsan, H., Aittom, K. Ä., Fares, A. E., Allen, J., Ambrosone, C. B., Amos, C. I., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Arnold, N., Aronson, K. J., Auber, B., Auer, P. L., Ausems, M. G. M., Azzollini, J., François, B., Balma, J. N., Barile, M., Barjhoux, L., Barkardottir, R. B., Barrdahl, M., Barnes, D., Barrowdale, D., Baynes, C., Beckmann, M. W., Benitez, J., Bermisheva, M., Bernstein, L., Bignon, Y. J., Blazer, K. R., Blok, M. J., Blomqvist, C., Blot, W., Bobolis, K., Boeckx, B., Bogdanova, N. V., Bojesen, A., Bojesen, S. E., Bonanni, B., Anne-Lise, B. D., Bozsik, A., Bradbury, A. R., Brand, J. S., Brauch, H., Brenner, H., Brigitte, B. D. P., Brewer, C., Brinton, L., Broberg, P., Angela, B. W., Brunet, J., Brüning, T., Burwinkel, B., Buys, S. S., Byun, J., Cai, Q., Cald, T. É., Caligo, M. A., Campbell, I., Canzian, F., Caron, O., Carracedo, A., Carter, B. D., Esteban, C., Castera, L., Virginie, C. M., Chan, S. B., Jenny, C. C., Chanock, S. J., Chen, X., Cheng, T. Y. D., Chiquette, J., Christiansen, H., Claes, K. B., Clarke, C. L., Conner, T., Conroy, D. M., Cook, J., Cordina-Duverger, E., Cornelissen, S., Coupier, I., Cox, A., Cox, D. G., Cross, S. S., Cuk, K., Cunningham, J. M., Czene, K., Daly, M. B., Damiola, F., Darabi, H., Davidson, R., Leeneer, K. D. L., Devilee, P., Dicks, E., Diez, O., Ding, Y. C., Ditsch, N., Doheny, K. F., Domchek, S. M., Dorfling, C. M., Dörk, T., Dos-Santos-Silva, I., Dubois, S., Dugué, P. A., Dumont, M., Dunning, A. M., Durcan, L., Dwek, M., Dworniczak, B., Eccles, D., Eeles, R., Ehrencrona, H., Eilber, U., Ejlertsen, B., Ekici, A. B., Eliassen, A. H., Engel, C., Eriksson, M., Fachal, L., Faivre, L., Fasching, P. A., Faust, U., Figueroa, J., Flesch-Janys, D., Fletcher, O., Flyger, H., Foulkes, W. D., Friedman, E., Fritschi, L., Frost, D., Gabrielson, M., Gaddam, P., Gammon, M. D., Ganz, P. A., Gapstur, S. M., Garber, J., Garcia-Barberan, V., Garciá-Saénz, J. A., Gaudet, M. M., Gauthier-Villars, M., Gehrig, A., Georgoulias, V., Gerdes, A. M., Giles, G. G., Glendon, G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., González-Neira, A., Goodfellow, P., Greene, M. H., Grenaker, G. A. I., Grip, M., Gronwald, J., Grundy, A., Gschwantler, D. K., Guénel, P., Guo, Q., Haeberle, L., Hahnen, E., Haiman, C. A., Håkansson, N., Hallberg, E., Hamann, U., Hamel, N., Hankinson, S., Hansen, T. V., Harrington, P., Hart, S. N., Hartikainen, J. M., Healey, C. S., Hein, A., Helbig, S., Henderson, A., Heyworth, J., Hicks, B., Hillemanns, P., Hodgson, S., Hogervorst, F. B., Hollestelle, A., Hooning, M. J., Hoover, B., Hopper, J. L., Hu, C., Huang, G., Hulick, P. J., Humphreys, K., Hunter, D. J., Imyanitov, E. N., Isaacs, C., Iwasaki, M., Izatt, L., Jakubowska, A., James, P., Janavicius, R., Janni, W., Jensen, U. B., John, E. M., Johnson, N., Jones, K., Jones, M., Jukkola-Vuorinen, A., Kaaks, R., Kabisch, M., Kaczmarek, K., Kang, D., Kast, K., Keeman, R., Kerin, M. J., Kets, C. M., Keupers, M. H., Khan, S., Khusnutdinova, E., Kiiski, J. I., Kim, S. W., Knight, J. A., Konstantopoulou, I., Kosma, V. M., Kristensen, V. N., Kruse, T. A., Kwong, A., Lænkholm, A. V., Laitman, Y., Lalloo, F., Lambrechts, D., Landsman, K., Lasset, C., Lazaro, C., Marchand, L. L., Al-Ejeh, F., Margreet, G. M. A., Bacot, F., Børresen-Dale, A. L., Bressac-De, B. P., Brooks-Wilson, A., Castelao, J. E., Caux-Moncoutier, V., Chang-Claude, J., McLaes, K. B., Dieter, F. J., Gschwantler-Kaulich, D., Lecarpentier, J., Lee, A., Lee, E., Won, J. L., Lee, M. H., Lejbkowicz, F., Lesueur, F., Li, J., Lilyquist, J., Lincoln, A., Lindblom, A., Lissowska, J., Lo, W. Y., Loibl, S., Long, J., Loud, J. T., Lubinski, J., Luccarini, C., Lush, M., MacInnis, R. J., Maishman, T., Makalic, E., Kostovska, I. M., Malone, K. E., Siranoush, M., Manson, J. E., Margolin, S., Martens, J. W., Martinez, M. E., Matsuo, K., Mavroudis, D., Mazoyer, S., McLean, C., Meijers-Heijboer, H., Menéndez, P., Meyer, J., Miao, H., Miller, N., Mitchell, G., Montagna, M., Muir, K., Mulligan, A. M., Mulot, C., Nadesan, S., Nathanson, K. L., Neuhausen, S. L., Nevanlinna, H., Nevelsteen, I., Niederacher, D., Nielsen, S. F., Nordestgaard, B. G., Norman, A., Nussbaum, R. L., Olah, E., Olopade, O. I., Olson, J. E., Olswold, C., Ong, K. R., Oosterwijk, J. C., Orr, N., Osorio, A., Pankratz, V. S., Papi, L., Park-Simon, T. W., Paulsson-Karlsson, Y., Lloyd, R., Pedersen, I. S., Peissel, B., Peixoto, A., Perez, J. I., Peterlongo, P., Peto, J., Pfeiler, G., Phelan, C. M., Pinchev, M., Plaseska-Karanfilska, D., Poppe, B., Porteous, M. E., Prentice, R., Presneau, N., Prokofieva, D., Pugh, E., Pujana, M. A., Pylkäs, K., Rack, B., Radice, P., Rahman, N., Rantala, J., Rappaport-Fuerhauser, C., Rennert, G., Rennert, H. S., Rhenius, V., Rhiem, K., Richardson, A., Rodriguez, G. C., Romero, A., Romm, J., Rookus, M. A., Rudolph, A., Ruediger, T., Saloustros, E., Sanders, J., Sandler, D. P., Sangrajrang, S., Sawyer, E. J., Schmidt, D. F., Schoemaker, M. J., Schumacher, F., Schürmann, P., Schwentner, L., Scott, C., Scott, R. J., Seal, S., Senter, L., Seynaeve, C., Shah, M., Sharma, P., Shen, C. Y., Sheng, X., Shimelis, H., Shrubsole, M. J., Shu, X. O., Side, L. E., Singer, C. F., Sohn, C., Southey, M. C., Spinelli, J. J., Spurdle, A. B., Stegmaier, C., Stoppa-Lyonnet, D., Sukiennicki, G., Surowy, H., Sutter, C., Swerdlow, A., Szabo, C. I., Tamimi, R. M., Tan, Y. Y., Taylor, J. A., Tejada, M. I., Tengström, M., Teo, S. H., Terry, M. B., Tessier, D. C., Teul, A. E., Thöne, K., Thull, D. L., Tibiletti, M. G., Tihomirova, L., Tischkowitz, M., Toland, A. E., Tollenaar, R. A. M., Tomlinson, I., Tong, L., Torres, D., Tranchant, M., Truong, T., Tucker, K., Tung, N., Tyrer, J., Ulmer, H. U., Vachon, C., Christi, V. A. J., Den Berg, D. V., Ouweland, A. M. V., Van Rensburg, E. J., Varesco, L., Varon-Mateeva, R., Vega, A., Viel, A., Vijai, J., Vincent, D., Vollenweider, J., Walker, L., Wang, Z., Wang-Gohrke, S., Wappenschmidt, B., Weinberg, C. R., Weitzel, J. N., Wendt, C., Wesseling, J., Whittemore, A. S., Wijnen, J. T., Willett, W., Winqvist, R., Wolk, A., Wu, A. H., Xia, L., Yang, X. R., Yannoukakos, D., Zaffaroni, D., Zheng, W., Zhu, B., Ziogas, A., Ziv, E., Zorn, K. K., Gago-Dominguez, M., Mannermaa, A., Olsson, H., Teixeira, M. R., Stone, J., Offit, K., Ottini, L., Park, S. K., Thomassen, M., Hall, P., Meindl, A., Schmutzler, R. K., Droit, A., Bader, G. D., Pharoah, P. D., Couch, F. J., Easton, D. F., Kraft, P., Chenevix-Trench, G., Garciá-Closas, M., Antoniou, A. C. & Simard, J., 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1767-1778 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

271 Citations (Scopus)

Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage

Betts, J. A., Moradi Marjaneh, M., Al-Ejeh, F., Lim, Y. C., Shi, W., Sivakumaran, H., Tropée, R., Patch, A. M., Clark, M. B., Bartonicek, N., Wiegmans, A. P., Hillman, K. M., Kaufmann, S., Bain, A. L., Gloss, B. S., Crawford, J., Kazakoff, S., Wani, S., Wen, S. W. & Day, B. & 11 others, Möller, A., Cloonan, N., Pearson, J., Brown, M. A., Mercer, T. R., Waddell, N., Khanna, K. K., Dray, E., Dinger, M. E., Edwards, S. L. & French, J. D., 3 Aug 2017, In: American Journal of Human Genetics. 101, 2, p. 255-266 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Citations (Scopus)

MITF and BRN2 contribute to metastatic growth after dissemination of melanoma

Simmons, J. L., Pierce, C. J., Al-Ejeh, F. & Boyle, G. M., 1 Dec 2017, In: Scientific Reports. 7, 1, 10909.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Citations (Scopus)

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

Ward, A., Dong, L., Harris, J. M., Khanna, K. K., Al-Ejeh, F., Fairlie, D. P., Wiegmans, A. P. & Liu, L., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3096-3100 5 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

Shi, W., Vu, T., Boucher, D., Biernacka, A., Nde, J., Pandita, R. K., Straube, J., Boyle, G. M., Al-Ejeh, F., Nag, P., Jeffery, J., Harris, J. L., Bain, A. L., Grzelak, M., Skrzypczak, M., Mitra, A., Dojer, N., Crosetto, N., Cloonan, N. & Becherel, O. J. & 8 others, Finnie, J., Skaar, J. R., Walkley, C. R., Pandita, T. K., Rowicka, M., Ginalski, K., Lane, S. W. & Khanna, K. K., 4 May 2017, In: Blood. 129, 18, p. 2471-2478 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

2016

Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer

Milevskiy, M. J. G., Al-Ejeh, F., Saunus, J. M., Northwood, K. S., Bailey, P. J., Betts, J. A., Reed, A. E. M. C., Nephew, K. P., Stone, A., Gee, J. M. W., Dowhan, D. H., Dray, E., Shewan, A. M., French, J. D., Edwards, S. L., Clark, S. J., Lakhani, S. R. & Brown, M. A., 1 Aug 2016, In: Human Molecular Genetics. 25, 15, p. 3269-3283 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Citations (Scopus)

RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy

Wiegmans, A. P., Miranda, M., Wen, S. W., Al-Ejeh, F. & Möller, A., 2016, In: Oncotarget. 7, 37, p. 60087-60100 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

2015

EphA2 is a therapy target in EphA2-positive leukemias but is not essential for normal hematopoiesis or leukemia

Charmsaz, S., Beckett, K., Smith, F. M., Bruedigam, C., Moore, A. S., Al-Ejeh, F., Lane, S. W. & Boyd, A. W., 17 Jun 2015, In: PLoS ONE. 10, 6, e0130692.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Nones, K., McCart Reed, A. E., Miller, D., Wilson, P. J., Al-Ejeh, F., Mariasegaram, M., Lau, Q., Withers, T., Jeffree, R. L., Reid, L. E., Da Silva, L., Matsika, A., Niland, C. M., Cummings, M. C. & Bruxner, T. J. C. & 32 others, Christ, A. N., Harliwong, I., Idrisoglu, S., Manning, S., Nourse, C., Nourbakhsh, E., Wani, S., Anderson, M. J., Fink, J. L., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Taylor, D., Waddell, N., Wood, S., Xu, Q., Kassahn, K. S., Narayanan, V., Taib, N. A., Teo, S. H., Chow, Y. P., Kconfa, B., Jat, P. S., Brandner, S., Flanagan, A. M., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. & Lakhani, S. R., Nov 2015, In: Journal of Pathology. 237, 3, p. 363-378 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Citations (Scopus)

MEK5-ERK5 pathway associates with poor survival of breast cancer patients after systemic treatments

Miranda, M., Rozali, E., Khanna, K. K. & Al-Ejeh, F., 2015, In: Oncoscience. 2, 2, p. 99-101 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

Using the MCF10A/MCF10CA1a breast cancer progression cell line model to investigate the effect of active, mutant forms of EGFR in breast cancer development and treatment using gefitinib

Bessette, D. C., Tilch, E., Seidens, T., Quinn, M. C. J., Wiegmans, A. P., Shi, W., Cocciardi, S., McCart-Reed, A., Saunus, J. M., Simpson, P. T., Grimmond, S. M., Lakhani, S. R., Khanna, K. K., Waddell, N., Al-Ejeh, F. & Chenevix-Trench, G., 13 May 2015, In: PLoS ONE. 10, 5, e0125232.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

2014

Eph family co-expression patterns define unique clusters predictive of cancer phenotype

Al-Ejeh, F., Offenhäuser, C., Lim, Y. C., Stringer, B. W., Day, B. W. & Boyd, A. W., 1 Dec 2014, In: Growth Factors. 32, 6, p. 254-264 11 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

Al-Ejeh, F., Pajic, M., Shi, W., Kalimutho, M., Miranda, M., Nagrial, A. M., Chou, A., Biankin, A. V., Grimmond, S. M., Brown, M. P. & Khanna, K. K., 15 Jun 2014, In: Clinical Cancer Research. 20, 12, p. 3187-3197 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Citations (Scopus)

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

Al-Ejeh, F., Miranda, M., Shi, W., Simpson, P. T., Song, S., Vargas, A. C., Saunus, J. M., Smart, C. E., Mariasegaram, M., Wiegmans, A. P., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 2014, In: Oncotarget. 5, 10, p. 3145-3158 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 1 Jan 2014, In: Oncogenesis. 3, 4, e100.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Citations (Scopus)

Postchemotherapy and tumor-selective targeting with the la-specific DAB4 monoclonal antibody relates to apoptotic cell clearance

Al-Ejeh, F., Staudacher, A. H., Smyth, D. R., Darby, J. M., Denoyer, D., Tsopelas, C., Hicks, R. J. & Brown, M. P., 1 May 2014, In: Journal of Nuclear Medicine. 55, 5, p. 772-779 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Rad51 supports triple negative breast cancer metastasis

Wiegmans, A. P., Al-Ejeh, F., Chee, N., Yap, P. Y., Gorski, J. J., Da Silva, L., Bolderson, E., Chenevix-Trench, G., Anderson, R., Simpson, P. T., Lakhani, S. R. & Khanna, K. K., 2014, In: Oncotarget. 5, 10, p. 3261-3272 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Citations (Scopus)

SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G₂ phase of cell cycle to prevent Re-replication

Johansson, P., Jeffery, J., Al-Ejeh, F., Schulz, R. B., Callen, D. F., Kumar, R. & Khanna, K. K., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18514-18525 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Citations (Scopus)

The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the la-specific antibody APOMAB®

Staudacher, A. H., Al-Ejeh, F., Fraser, C. K., Darby, J. M., Roder, D. M., Ruszkiewicz, A., Manavis, J. & Brown, M. P., 2014, In: EJNMMI Research. 4, 1, p. 1-13 13 p., 2.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

2013

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

Day, B. W., Stringer, B. W., Al-Ejeh, F., Ting, M. J., Wilson, J., Ensbey, K. S., Jamieson, P. R., Bruce, Z. C., Lim, Y. C., Offenhäuser, C., Charmsaz, S., Cooper, L. T., Ellacott, J. K., Harding, A., Leveque, L., Inglis, P., Allan, S., Walker, D. G., Lackmann, M. & Osborne, G. & 4 others, Khanna, K. K., Reynolds, B. A., Lickliter, J. D. & Boyd, A. W., 11 Feb 2013, In: Cancer Cell. 23, 2, p. 238-248 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

181 Citations (Scopus)

Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2

Shi, W., Bain, A. L., Schwer, B., Al-Ejeh, F., Smith, C., Wong, L., Chai, H., Miranda, M. S., Ho, U., Kawaguchi, M., Miura, Y., Finnie, J. W., Wall, M., Heierhorst, J., Wicking, C., Spring, K. J., Alt, F. W. & Khanna, K. K., Feb 2013, In: PLoS Genetics. 9, 2, e1003298.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

Al-Ejeh, F., Shi, W., Miranda, M., Simpson, P. T., Vargas, A. C., Song, S., Wiegmans, A. P., Swarbrick, A., Welm, A. L., Brown, M. P., Chenevix-Trench, G., Lakhani, S. R. & Khanna, K. K., 1 Jun 2013, In: Journal of Nuclear Medicine. 54, 6, p. 913-921 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Citations (Scopus)

2012

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

Noll, J. E., Jeffery, J., Al-Ejeh, F., Kumar, R., Khanna, K. K., Callen, D. F. & Neilsen, P. M., 7 Jun 2012, In: Oncogene. 31, 23, p. 2836-2848 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Citations (Scopus)

Tocotrienol as a potential anticancer agent

Ling, M. T., Luk, S. U., Al-Ejeh, F. & Khanna, K. K., 1 Feb 2012, In: Carcinogenesis. 33, 2, p. 233-239 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Citations (Scopus)

2011

Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges

Simpson, P. T., Vargas, A. C., Al-Ejeh, F., Khanna, K. K., Chenevix-Trench, G. & Lakhani, S. R., Feb 2011, In: Human Pathology. 42, 2, p. 153-165 13 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

Neilsen, P. M., Noll, J. E., Suetani, R. J., Schulz, R. B., Al-Ejeh, F., Evdokiou, A., Lane, D. P. & Callen, D. F., Dec 2011, In: Oncotarget. 2, 12, p. 1203-1217 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Citations (Scopus)

Nutlin-3a is a potential therapeutic for Ewing sarcoma

Pishas, K. I., Al-Ejeh, F., Zinonos, I., Kumar, R., Evdokiou, A., Brown, M. P., Callen, D. F. & Neilsen, P. M., 1 Feb 2011, In: Clinical Cancer Research. 17, 3, p. 494-504 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Citations (Scopus)

Plasma functionalized PDMS microfluidic chips: Towards point-of-care capture of circulating tumor cells

Kurkuri, M. D., Al-Ejeh, F., Shi, J. Y., Palms, D., Prestidge, C., Griesser, H. J., Brown, M. P. & Thierry, B., 28 Jun 2011, In: Journal of Materials Chemistry. 21, 24, p. 8841-8848 8 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

2009

APOMAB®, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

Al-Ejeh, F., Darby, J. M., Tsopelas, C., Smyth, D., Manavis, J. & Brown, M. P., 27 Feb 2009, In: PLoS ONE. 4, 2, e4558.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

Al-Ejeh, F., Darby, J. M., Thierry, B. & Brown, M. P., May 2009, In: Nuclear Medicine and Biology. 36, 4, p. 395-402 8 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Dr. Fares Hisham Subhi Al Ejeh

Research output

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