Projects per year
Personal profile
Biography
Dr Khan is an Assistant Professor at the College of Health and Life Sciences at Hamad Bin Khalifa University. Dr. Khan completed his Master's in Molecular Cell Biology from Uppsala University, and then a PhD in the lab of Prof. Martin Bergo, a protein lipidation expert. In Bergo's lab, he identified the biochemical importance of the protein lipidation enzyme GGTase-I in immune cell function. He refuted the popular idea that GGTase-I can be a therapeutic target against inflammatory conditions.
After finishing his PhD, he moved to The Francis Crick Institute (London) in Dr. Axel Behrens's Lab, where he worked on identifying the posttranslational regulators of a tumor suppressor protein FBW7 and mechanisms of chemotherapy resistance in cancer. Dr Khan’s postdoc work highlighted the importance of protein ubiquitylation and protein turnover in colorectal cancer. He found that FBW7 which is a tumor suppressor, is posttranslationally downregulated in several colorectal cancers. These findings challenge the popular belief that only somatic loss of function mutations can contribute to cancer development.
Dr Khan's lab now focusses on the posttranslational modifications like ubiquitylation and phosphorylation in colorectal cancer and cancer chemotherapy resistance. Findings from his lab has also embarked his team on identifying regulators of TGFb signaling in human cancers which is a major tumor suppressor pathway involved in cancer cell metastasis in later stages of cancer. His lab is funded by NPRP and Worldwide Cancer grants from Qatar national research fund and Worldwide Cancer Research respectively!
Education/Academic qualification
Molecular Medicine, PhD, Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis, University of Gothenburg
15 Jan 2007 → 24 May 2012
Award Date: 24 May 2012
Molecular Cell Biology, Master, Potentiation of chemotherapy drugs by glucose analogs , Uppsala University
15 Jan 2005 → 30 Sept 2006
Award Date: 30 Sept 2006
External positions
Postdoctoral Scientist, The Francis Crick Institute
1 Jan 2013 → 31 Dec 2018
Keywords
- Q Science (General)
- Colorectal Cancer
- Protein Posttranslational Modifications
- Ubiquitylation
- Phosphorylation
- R Medicine (General)
- Precision Medicine
- Chemotherapy resistance
- Pancreatic Cancer
- Cancer metastasis
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
HBKU-OVPR-TG-01-3: Validation of LDHC as a novel target for precision medicine in breast cancer
Decock, J. V. C. M. (Lead Principal Investigator), Khan, O. M. (Principal Investigator) & Kohil, A. (Graduate Student)
1/06/21 → 30/11/23
Project: Experimental Development/Translation Research
-
EX-QNRF-NPRPS-23: A PRECISION MEDICINE APPROACH TO TARGET COLORECTAL CANCER
Farhan, M. (Principal Investigator), Khan, O. M. (Lead Principal Investigator), Keyan, K. (Graduate Student) & Kohil, A. (Graduate Student)
15/03/21 → 15/03/25
Project: Experimental Development/Translation Research
-
EX-WCRF-RG-1: Targeting gemcitabine resistance in pancreatic cancer
Khan, O. M. (Lead Principal Investigator) & Al Haj Zen, A. (Co-Lead Principal Investigator)
1/03/25 → 29/02/28
Project: Basic Research
-
Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12
Keyan, K. S., Salim, S., Gowda, S., Abdelrahman, D., Amir, S. S., Islam, Z., Vargas, C., Bengoechea-Alonso, M. T., Alwa, A., Dahal, S., Kolatkar, P. R., Da’as, S., Torrisani, J., Ericsson, J., Mohammad, F. & Khan, O. M., Oct 2023, In: Cell Death and Disease. 14, 10, 692.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2
Jiménez-Izquierdo, R., Morrugares, R., Suanes-Cobos, L., Correa-Sáez, A., Garrido-Rodríguez, M., Cerero-Tejero, L., Khan, O. M., de la Luna, S., Sancho, R. & Calzado, M. A., 18 Mar 2023, In: Cell Death and Disease. 14, 3, 14 p., 202.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
Khan, O. M., Carvalho, J., Spencer-Dene, B., Mitter, R., Frith, D., Snijders, A. P., Wood, S. A. & Behrens, A., 2 Apr 2018, In: Journal of Clinical Investigation. 128, 4, p. 1326-1337 12 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Citations (Scopus) -
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
Khan, O. M., Almagro, J., Nelson, J. K., Horswell, S., Encheva, V., Keyan, K. S., Clurman, B. E., Snijders, A. P. & Behrens, A., 1 Dec 2021, In: Nature Communications. 12, 1, 2043.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
E3 Ubiquitin Ligase TRIP12 Controls Exit from Mitosis via Positive Regulation of MCL-1 in Response to Taxol
Keyan, K. S., Alanany, R., Kohil, A. & Khan, O. M., Jan 2023, In: Cancers. 15, 2, 505.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)