Identification of novel prognostic and therapeutic targets for breast cancer

  • Alajez, Nehad (Lead Principal Investigator)
  • Abdel-Razeq, Dr.Hikmat (Principal Investigator)
  • Al-Omari, Dr.Amal (Principal Investigator)
  • Tbakhi, Dr.Abdelghani (Principal Investigator)

Project: Experimental Development/Translation Research

Project Details

Abstract

This project aims to identify the molecular signatures associated with response to neoadjuvant therapy in breast cancer (BC). Secondly, the proposal aims to identify the mRNAs and ncRNAs that mediate resistance to chemotherapy in BC cell models using functional CRISPR-Cas9 library screens. Findings from this project could lead to the identification of novel therapeutic targets for BC and could ultimately help direct treatment choices.

Submitting Institute Name

Hamad Bin Khalifa University (HBKU)
Sponsor's Award NumberIGP5-2022-006
Proposal IDQBRI-CORE-000007
StatusActive
Effective start/end date1/01/23 → 31/12/25

Collaborative partners

Primary Theme

  • Precision Health

Primary Subtheme

  • PH - Diagnosis Treatment

Secondary Theme

  • None

Secondary Subtheme

  • None

Keywords

  • Breast cancer, Neoadjuvant therapy, mRNAs. ncRNAs, CRISPR-Cas9, Therapeutic targets
  • None

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