Project Details
Abstract
Autism Spectrum Disorders (ASD) encompass a range of neurodevelopmental disorders characterized by behavioral, communication, and social deficits. Despite the involvement of numerous genetic variants and genes in ASD, only a few have been validated. Additionally, the molecular events underlying ASD development remain poorly understood. Establishing a precision medicine pipeline is crucial to validating genetic variants and uncovering molecular mechanisms. This proposal aims to establish a comprehensive precision medicine pipeline in Qatar for ASD research. Given the complexity of ASD and the multitude of variants implicated, integrating multiple approaches is necessary. We have identified Chromodomain-helicase-DNA-binding (CHD) proteins as a promising target. CHD proteins modify gene expression by altering chromatin structure. Notably, CHD1/2 mutations have been linked to ASD, with CHD2 showing a strong burden of de novo point mutations.
Submitting Institute Name
Hamad Bin Khalifa University (HBKU)
| Sponsor's Award Number | ARG02-0408-240151 |
|---|---|
| Proposal ID | EX-QNRF-ARG-184 |
| Status | Active |
| Effective start/end date | 15/04/25 → 15/04/28 |
Primary Theme
- Precision Health
Primary Subtheme
- PH - National Health Mapping Programs
Secondary Theme
- None
Secondary Subtheme
- None
Keywords
- Autism Spectrum Disorders
- Molecular Dynamics Simulations
- Genetics and Genomics
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