Unlocking precision medicine in breast cancer: Generation of a Breast cancer Cancer Testis antigen Atlas (BCTa) for biomarker discovery and therapeutic target identification.

Breast cancer poses a global health challenge, accounting for the majority of cancer cases and the highest mortality rate in women. Despite significant advances in cancer therapeutics, there is still an unmet need for effective therapies with durable and tumor-specific responses. Cancer testis antigens (CTAs) have emerged as promising targets for cancer therapy due to their restricted expression in normal tissues, re-expression in tumors and immunogenic nature. However, their expression, clinical relevance and molecular functions in breast cancer remain largely unknown.

Hamad Bin Khalifa University (HBKU)