AgCuB nanoparticle eradicates intracellular S. aureus infection in bone cells: in vitro

Shahnaz Qadri; Tahir Abdulrehman; Jamil Azzi; Said Mansour; Yousef Haik

doi:10.1007/s42247-019-00035-7

AgCuB nanoparticle eradicates intracellular S. aureus infection in bone cells: in vitro

Shahnaz Qadri, Tahir Abdulrehman, Jamil Azzi, Said Mansour, Yousef Haik^*

^*Corresponding author for this work

Core Laboratories

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14 Citations (Scopus)

Abstract

Staphylococcus aureus is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.

Original language	English
Pages (from-to)	219-231
Number of pages	13
Journal	Emergent Materials
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/s42247-019-00035-7
Publication status	Published - 1 Jun 2019

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title = "AgCuB nanoparticle eradicates intracellular S. aureus infection in bone cells: in vitro",

abstract = "Staphylococcus aureus is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP{\textquoteright}s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.",

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T1 - AgCuB nanoparticle eradicates intracellular S. aureus infection in bone cells

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AU - Qadri, Shahnaz

AU - Abdulrehman, Tahir

AU - Azzi, Jamil

AU - Mansour, Said

AU - Haik, Yousef

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N2 - Staphylococcus aureus is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.

AB - Staphylococcus aureus is the leading cause of internalized bone infection. Internalized bacteria are shielded from the immune system and antibiotics causing complications of conventional antibiotic treatment. In this study, we investigate silver-copper-boron (AgCuB) nanoparticles (NPs) as a potential alternative to eradicate internalized bacterial infection without causing a harming effect on the host cells. The antimicrobial property, as well as the toxicity of the AgCuB NP’s, is reported as dose-dependent between 0 and 20 μg/ml. Our results showed that 1–5 μg/ml of AgCuB NPs significantly reduced internalized infection in osteoblast cells with a single dose of treatment. The host cell toxicity observed at 20 μg/ml is ten times higher than the effective antimicrobial dose.

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AgCuB nanoparticle eradicates intracellular S. aureus infection in bone cells: in vitro

Abstract

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