Altered patterns of gene expression in response to myocardial infarction

Lawrence W. Stanton, Lisa J. Garrard, Deborah Damm, Brett L. Garrick, Andrew Lam, Ann M. Kapoun, Qiang Zheng, Andrew A. Protter, George F. Schreiner, R. Tyler White*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

332 Citations (Scopus)

Abstract

The use of cDNA microarrays has made it possible to simultaneously analyze gene expression for thousands of genes. Microarray technology was used to evaluate the expression of >4000 genes in a rat model of myocardial infarction. More than 200 genes were identified that showed differential expression in response to myocardial infarction. Gene expression changes were monitored from 2 to 16 weeks after infarction in 2 regions of the heart, the left ventricle free wall and interventricular septum. A novel clustering program was used to identify patterns of expression within this large set of data. Unique patterns were revealed within the transcriptional responses that illuminate changes in biological processes associated with myocardial infarction.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalCirculation Research
Volume86
Issue number9
DOIs
Publication statusPublished - 12 May 2000
Externally publishedYes

Keywords

  • DNA microassays
  • Gene expression
  • Myocardial infarction
  • Tissue remodeling

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