An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

Abdelilah Arredouani; A. Mark Evans; Jianjie Ma; John Parrington; Michael X. Zhu; Antony Galione

doi:10.4161/isl.2.5.12747

An emerging role for NAADP-mediated Ca²⁺ signaling in the pancreatic β-cell

Abdelilah Arredouani, A. Mark Evans, Jianjie Ma, John Parrington, Michael X. Zhu, Antony Galione^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

28 Citations (Scopus)

Abstract

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.^1-5 These studies have highlighted a role for NAADP-induced Ca²⁺ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

Original language	English
Journal	Islets
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/isl.2.5.12747
Publication status	Published - Sept 2010
Externally published	Yes

Keywords

Calcium lysosome
NAADP
Pancreatic β-cell
Two-pore channel (TPC)

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10.4161/isl.2.5.12747

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title = "An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell",

abstract = "Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.",

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AU - Arredouani, Abdelilah

AU - Evans, A. Mark

AU - Ma, Jianjie

AU - Parrington, John

AU - Zhu, Michael X.

AU - Galione, Antony

PY - 2010/9

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N2 - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

AB - Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signaling in pancreatic β-cells.1-5 These studies have highlighted a role for NAADP-induced Ca2+ mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

KW - Calcium lysosome

KW - NAADP

KW - Pancreatic β-cell

KW - Two-pore channel (TPC)

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M3 - Comment/debate

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AN - SCOPUS:77957361860

SN - 1938-2014

VL - 2

JO - Islets

JF - Islets

IS - 5

ER -

An emerging role for NAADP-mediated Ca²⁺ signaling in the pancreatic β-cell

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Keywords

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