An evaluation of the role of the exercise training dose for changes in exercise capacity following a standard cardiac rehabilitation program

Background: To retrospectively characterize and compare the dose of exercise training (ET) within a large cohort of patients demonstrating different levels of improvement in exercise capacity following a cardiac rehabilitation (CR) program. Methods: A total of 2310 patients who completed a 12-week, center-based, guidelines-informed CR program between January 2018 and December 2019 were included in the analysis. Peak metabolic equivalents (MET_peak) were determined pre- and post-CR during which total duration (ET time) and intensity [percent of heart rate peak (%HR_peak)] of supervised ET were also obtained. Training responsiveness was quantified on the basis of changes in MET_peak from pre- to post-CR. A cluster analysis was performed to identity clusters demonstrating discrete levels of responsiveness (i.e., negative, low, moderate, high, and very-high). These were compared for several baseline and ET-derived variables which were also included in a multivariable linear regression model. Results: At pre-CR, baseline MET_peak was progressively lower with greater training responsiveness (F_(4,2305) = 44.2, P < 0.01, η²_p = 0.71). Likewise, average training duration (F_(4,2305) = 10.7 P < 0.01, η²_p = 0.02) and %HR_peak (F_(4,2305) = 25.1 P < 0.01, η²_p = 0.042) quantified during onsite ET sessions were progressively greater with greater training responsiveness. The multivariable linear regression model confirmed that baseline MET_peak, training duration and intensity during ET, BMI, and age (P < 0.001) were significant predictors of MET_peak post-CR. Conclusions: Along with baseline MET_peak, delta BMI, and age, the dose of ET (i.e., training duration and intensity) predicts MET_peak at the conclusion of CR. A re-evaluation of current approaches for exercise intensity prescription is recommended to extend the benefits of completing CR to all patients.