Antioxidants and Restenosis after Percutaneous Coronary Intervention: Animal Studies

Eric Durand; Ayman Al Haj Zen; Camille Brasselet; Antoine Lafont

doi:10.1007/0-387-29553-4_13

Antioxidants and Restenosis after Percutaneous Coronary Intervention: Animal Studies

Eric Durand, Ayman Al Haj Zen, Camille Brasselet, Antoine Lafont

INSERM

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Restenosis remains the principal limitation of percutaneous coronary
intervention (PCI). We have learned from animal studies that constrictive
remodeling is the principal mechanism of restenosis after balloon
angioplasty. In contrast, in-stent restenosis is related to neointimal
hyperplasia. These data were confirmed in humans by intravascular
ultrasound (IVUS). After balloon arterial injury, oxidative stress is
increased and contributes to endothelial dysfunction, macrophage activation,
and release of cytokines and growth factors. In the past decade, several
antioxidants have been evaluated in various animal models after balloon
angioplasty. Probucol and vitamins (E with or without C) effectively
reduced restenosis by promoting favorable remodeling (i.e., enlargement
remodeling). Moreover, these treatments decreased neointimal hyperplasia
which is the target for in-stent restenosis. In an era of nearly 100% stent
implantation, it is now time to evaluate their efficacy in animal models of instent restenosis after either systemic administration or local delivery.

Original language	Undefined/Unknown
Title of host publication	Antioxidants and Cardiovascular Disease
DOIs	https://doi.org/10.1007/0-387-29553-4_13
Publication status	Published - 2006
Externally published	Yes

Access to Document

10.1007/0-387-29553-4_13

Cite this

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title = "Antioxidants and Restenosis after Percutaneous Coronary Intervention: Animal Studies",

abstract = "Restenosis remains the principal limitation of percutaneous coronaryintervention (PCI). We have learned from animal studies that constrictiveremodeling is the principal mechanism of restenosis after balloonangioplasty. In contrast, in-stent restenosis is related to neointimalhyperplasia. These data were confirmed in humans by intravascularultrasound (IVUS). After balloon arterial injury, oxidative stress isincreased and contributes to endothelial dysfunction, macrophage activation,and release of cytokines and growth factors. In the past decade, severalantioxidants have been evaluated in various animal models after balloonangioplasty. Probucol and vitamins (E with or without C) effectivelyreduced restenosis by promoting favorable remodeling (i.e., enlargementremodeling). Moreover, these treatments decreased neointimal hyperplasiawhich is the target for in-stent restenosis. In an era of nearly 100% stentimplantation, it is now time to evaluate their efficacy in animal models of instent restenosis after either systemic administration or local delivery. ",

author = "Eric Durand and Zen, {Ayman Al Haj} and Camille Brasselet and Antoine Lafont",

year = "2006",

doi = "10.1007/0-387-29553-4_13",

language = "Undefined/Unknown",

isbn = "9780387295527",

booktitle = "Antioxidants and Cardiovascular Disease",

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T1 - Antioxidants and Restenosis after Percutaneous Coronary Intervention: Animal Studies

AU - Durand, Eric

AU - Zen, Ayman Al Haj

AU - Brasselet, Camille

AU - Lafont, Antoine

PY - 2006

Y1 - 2006

N2 - Restenosis remains the principal limitation of percutaneous coronaryintervention (PCI). We have learned from animal studies that constrictiveremodeling is the principal mechanism of restenosis after balloonangioplasty. In contrast, in-stent restenosis is related to neointimalhyperplasia. These data were confirmed in humans by intravascularultrasound (IVUS). After balloon arterial injury, oxidative stress isincreased and contributes to endothelial dysfunction, macrophage activation,and release of cytokines and growth factors. In the past decade, severalantioxidants have been evaluated in various animal models after balloonangioplasty. Probucol and vitamins (E with or without C) effectivelyreduced restenosis by promoting favorable remodeling (i.e., enlargementremodeling). Moreover, these treatments decreased neointimal hyperplasiawhich is the target for in-stent restenosis. In an era of nearly 100% stentimplantation, it is now time to evaluate their efficacy in animal models of instent restenosis after either systemic administration or local delivery.

AB - Restenosis remains the principal limitation of percutaneous coronaryintervention (PCI). We have learned from animal studies that constrictiveremodeling is the principal mechanism of restenosis after balloonangioplasty. In contrast, in-stent restenosis is related to neointimalhyperplasia. These data were confirmed in humans by intravascularultrasound (IVUS). After balloon arterial injury, oxidative stress isincreased and contributes to endothelial dysfunction, macrophage activation,and release of cytokines and growth factors. In the past decade, severalantioxidants have been evaluated in various animal models after balloonangioplasty. Probucol and vitamins (E with or without C) effectivelyreduced restenosis by promoting favorable remodeling (i.e., enlargementremodeling). Moreover, these treatments decreased neointimal hyperplasiawhich is the target for in-stent restenosis. In an era of nearly 100% stentimplantation, it is now time to evaluate their efficacy in animal models of instent restenosis after either systemic administration or local delivery.

U2 - 10.1007/0-387-29553-4_13

DO - 10.1007/0-387-29553-4_13

M3 - Chapter

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