TY - JOUR
T1 - Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status
T2 - Triple positive tumours are more likely lymph node positive
AU - Van Calster, Ben
AU - Vanden Bempt, Isabelle
AU - Drijkoningen, Maria
AU - Pochet, Nathalie
AU - Cheng, Jiqiu
AU - Van Huffel, Sabine
AU - Hendrickx, Wouter
AU - Decock, Julie
AU - Huang, Huei Jean
AU - Leunen, Karin
AU - Amant, Frederic
AU - Berteloot, Patrick
AU - Paridaens, Robert
AU - Wildiers, Hans
AU - Van Limbergen, Erik
AU - Weltens, Caroline
AU - Timmerman, Dirk
AU - Van Gorp, Toon
AU - Smeets, Ann
AU - Van Den Bogaert, Walter
AU - Vergote, Ignace
AU - Christiaens, Marie Rose
AU - Neven, Patrick
PY - 2009/1
Y1 - 2009/1
N2 - Aims: To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status. Methods: 2227 recently operated cases in one centre were retrieved from the Multidisciplinary Breast Centre database and stratified according to their combined immunohistochemical (IHC) expression of ER/PR/HER-2 status. An equivocal HER-2 status was further analysed by Fluorescence in situ Hybridisation (FISH). The following 6 groups were considered: ER-PR-HER-2- (NNN; triple negative), ER-PR-HER-2+ (NNP), ER +PR-HER-2- (PNN), ER+PR -HER-2+ (PNP), ER+PR+HER-2 - (PPN), ER+PR+HER-2+ (PPP; triple positive). For ALN, the following variables were tested in uni- and multivariate models: age at diagnosis (years), tumour size (mm), tumour grade, ER, PR, HER-2 and the combined steroid receptor and HER-2 status. Likelihood ratio χ2-tests were used for univariate analysis and logistic regression for multivariate analysis. Results: Triple positive tumours had a higher likelihood of being ALN positive than others (56.2% versus 35.7%; P < 0.0001). Univariate logistic regression also withheld age, size, grade and HER-2 as predictors of ALN involvement. Final multivariate logistic regression revealed age, size, grade and PPP versus non-PPP to be independent predictors of ALN involvement; the odds ratio (OR) and 95% CI for PPP versus non-PPP tumours was 2.169 (1.490-3.156). Conclusion: Our data provide insight into the natural history of triple positive breast carcinomas. Such tumours are more likely ALN positive than those with another steroid receptor and HER-2 status. How these findings correlate with breast cancer prognosis remains to be investigated.
AB - Aims: To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status. Methods: 2227 recently operated cases in one centre were retrieved from the Multidisciplinary Breast Centre database and stratified according to their combined immunohistochemical (IHC) expression of ER/PR/HER-2 status. An equivocal HER-2 status was further analysed by Fluorescence in situ Hybridisation (FISH). The following 6 groups were considered: ER-PR-HER-2- (NNN; triple negative), ER-PR-HER-2+ (NNP), ER +PR-HER-2- (PNN), ER+PR -HER-2+ (PNP), ER+PR+HER-2 - (PPN), ER+PR+HER-2+ (PPP; triple positive). For ALN, the following variables were tested in uni- and multivariate models: age at diagnosis (years), tumour size (mm), tumour grade, ER, PR, HER-2 and the combined steroid receptor and HER-2 status. Likelihood ratio χ2-tests were used for univariate analysis and logistic regression for multivariate analysis. Results: Triple positive tumours had a higher likelihood of being ALN positive than others (56.2% versus 35.7%; P < 0.0001). Univariate logistic regression also withheld age, size, grade and HER-2 as predictors of ALN involvement. Final multivariate logistic regression revealed age, size, grade and PPP versus non-PPP to be independent predictors of ALN involvement; the odds ratio (OR) and 95% CI for PPP versus non-PPP tumours was 2.169 (1.490-3.156). Conclusion: Our data provide insight into the natural history of triple positive breast carcinomas. Such tumours are more likely ALN positive than those with another steroid receptor and HER-2 status. How these findings correlate with breast cancer prognosis remains to be investigated.
KW - Breast cancer
KW - HER-2
KW - Lymph node
KW - Steroid receptors
UR - http://www.scopus.com/inward/record.url?scp=58049213826&partnerID=8YFLogxK
U2 - 10.1007/s10549-008-9914-7
DO - 10.1007/s10549-008-9914-7
M3 - Article
C2 - 18264760
AN - SCOPUS:58049213826
SN - 0167-6806
VL - 113
SP - 181
EP - 187
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -