TY - JOUR
T1 - Biomedical,clinical and environmental applications of platinum-based nanohybrids
T2 - An updated review
AU - Yerpude, Sachin T.
AU - Potbhare, Ajay K.
AU - Bhilkar, Pavan
AU - Rai, Alok R.
AU - Singh, Raghvendra P.
AU - Abdala, Ahmed A.
AU - Adhikari, Rameshwar
AU - Sharma, Rohit
AU - Chaudhary, Ratiram G.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/8/15
Y1 - 2023/8/15
N2 - Platinum nanoparticles (Pt NPs) have numerous applications in various sectors, including pharmacology, nanomedicine, cancer therapy, radiotherapy, biotechnology and environment mitigation like removal of toxic metals from wastewater, photocatalytic degradation of toxic compounds, adsorption, and water splitting. The multifaceted applications of Pt NPs because of their ultra-fine structures, large surface area, tuned porosity, coordination-binding, and excellent physiochemical properties. The various types of nanohybrids (NHs) of Pt NPs can be fabricated by doping with different metal/metal oxide/polymer-based materials. There are several methods to synthesize platinum-based NHs, but biological processes are admirable because of green, economical, sustainable, and non-toxic. Due to the robust physicochemical and biological characteristics of platinum NPs, they are widely employed as nanocatalyst, antioxidant, antipathogenic, and anticancer agents. Indeed, Pt-based NHs are the subject of keen interest and substantial research area for biomedical and clinical applications. Hence, this review systematically studies antimicrobial, biological, and environmental applications of platinum and platinum-based NHs, predominantly for treating cancer and photo-thermal therapy. Applications of Pt NPs in nanomedicine and nano-diagnosis are also highlighted. Pt NPs-related nanotoxicity and the potential and opportunity for future nano-therapeutics based on Pt NPs are also discussed.
AB - Platinum nanoparticles (Pt NPs) have numerous applications in various sectors, including pharmacology, nanomedicine, cancer therapy, radiotherapy, biotechnology and environment mitigation like removal of toxic metals from wastewater, photocatalytic degradation of toxic compounds, adsorption, and water splitting. The multifaceted applications of Pt NPs because of their ultra-fine structures, large surface area, tuned porosity, coordination-binding, and excellent physiochemical properties. The various types of nanohybrids (NHs) of Pt NPs can be fabricated by doping with different metal/metal oxide/polymer-based materials. There are several methods to synthesize platinum-based NHs, but biological processes are admirable because of green, economical, sustainable, and non-toxic. Due to the robust physicochemical and biological characteristics of platinum NPs, they are widely employed as nanocatalyst, antioxidant, antipathogenic, and anticancer agents. Indeed, Pt-based NHs are the subject of keen interest and substantial research area for biomedical and clinical applications. Hence, this review systematically studies antimicrobial, biological, and environmental applications of platinum and platinum-based NHs, predominantly for treating cancer and photo-thermal therapy. Applications of Pt NPs in nanomedicine and nano-diagnosis are also highlighted. Pt NPs-related nanotoxicity and the potential and opportunity for future nano-therapeutics based on Pt NPs are also discussed.
KW - Anticancer
KW - Clinical assay
KW - Environmental mitigation
KW - Nanomedicine
KW - Nanotoxicity
KW - Platinum -based NHs
KW - Water splitting
UR - http://www.scopus.com/inward/record.url?scp=85161719476&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2023.116148
DO - 10.1016/j.envres.2023.116148
M3 - Review article
C2 - 37211181
AN - SCOPUS:85161719476
SN - 0013-9351
VL - 231
JO - Environmental Research
JF - Environmental Research
M1 - 116148
ER -