Chiral bicyclic tetramates as non-planar templates for chemical library synthesis

Muhammad Anwar; Mark G. Moloney

doi:10.1111/cbdd.12110

Chiral bicyclic tetramates as non-planar templates for chemical library synthesis

Muhammad Anwar, Mark G. Moloney^*

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Chemoselective Dieckmann cyclization reactions may be used on oxazolidine and thiazolidine templates derived from various aldehydes to access bicyclic tetramates, which have potential as templates for chemical library construction. Bioassay against Staphylococcus aureus and Escherichia coli showed that these systems have little or no intrinsic antibacterial bioactivity.

Original language	English
Pages (from-to)	645-649
Number of pages	5
Journal	Chemical Biology and Drug Design
Volume	81
Issue number	5
DOIs	https://doi.org/10.1111/cbdd.12110
Publication status	Published - May 2013
Externally published	Yes

Keywords

Chemical structure
Cheminformatics
Combinatorial chemistry
Drug design

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10.1111/cbdd.12110

Cite this

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abstract = "Chemoselective Dieckmann cyclization reactions may be used on oxazolidine and thiazolidine templates derived from various aldehydes to access bicyclic tetramates, which have potential as templates for chemical library construction. Bioassay against Staphylococcus aureus and Escherichia coli showed that these systems have little or no intrinsic antibacterial bioactivity.",

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AB - Chemoselective Dieckmann cyclization reactions may be used on oxazolidine and thiazolidine templates derived from various aldehydes to access bicyclic tetramates, which have potential as templates for chemical library construction. Bioassay against Staphylococcus aureus and Escherichia coli showed that these systems have little or no intrinsic antibacterial bioactivity.

KW - Chemical structure

KW - Cheminformatics

KW - Combinatorial chemistry

KW - Drug design

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Chiral bicyclic tetramates as non-planar templates for chemical library synthesis

Abstract

Keywords

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