Click-based synthesis and proteomic profiling of lipstatin analogues

Mun H. Ngai; Peng Yu Yang; Kai Liu; Yuan Shen; Markus R. Wenk; Shao Q. Yao; Martin J. Lear

doi:10.1039/c0cc01276a

Click-based synthesis and proteomic profiling of lipstatin analogues

Mun H. Ngai, Peng Yu Yang, Kai Liu, Yuan Shen, Markus R. Wenk, Shao Q. Yao, Martin J. Lear

National University of Singapore

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

Original language	English
Pages (from-to)	8335-8337
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	44
DOIs	https://doi.org/10.1039/c0cc01276a
Publication status	Published - 28 Nov 2010
Externally published	Yes

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title = "Click-based synthesis and proteomic profiling of lipstatin analogues",

abstract = "Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.",

author = "Ngai, {Mun H.} and Yang, {Peng Yu} and Kai Liu and Yuan Shen and Wenk, {Markus R.} and Yao, {Shao Q.} and Lear, {Martin J.}",

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AU - Ngai, Mun H.

AU - Yang, Peng Yu

AU - Liu, Kai

AU - Shen, Yuan

AU - Wenk, Markus R.

AU - Yao, Shao Q.

AU - Lear, Martin J.

PY - 2010/11/28

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N2 - Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

AB - Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

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U2 - 10.1039/c0cc01276a

DO - 10.1039/c0cc01276a

M3 - Article

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EP - 8337

JO - Chemical Communications

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Click-based synthesis and proteomic profiling of lipstatin analogues

Abstract

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