Abstract
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.
Original language | English |
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Pages (from-to) | 8335-8337 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 44 |
DOIs | |
Publication status | Published - 28 Nov 2010 |
Externally published | Yes |