Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

Mustapha Aouida, Omar Tounekti, Omrane Belhadj, Lluis M. Mir*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.

Original languageEnglish
Pages (from-to)2012-2014
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number6
DOIs
Publication statusPublished - 1 Jun 2003
Externally publishedYes

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