TY - JOUR
T1 - Degradation assessment of Mg-Incorporated 3D printed PLA scaffolds for biomedical applications
AU - Ali, Fawad
AU - Kalva, Sumama N.
AU - Mroue, Kamal H.
AU - Keyan, Kripa S.
AU - Tong, Yongfeng
AU - Khan, Omar M.
AU - Koç, Muammer
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/11
Y1 - 2023/11
N2 - Polylactic acid (PLA)/Magnesium (Mg)-based composites exhibit great potential for applications in bone regeneration and tissue engineering. PLA is a biodegradable and biocompatible polymer, that has the ability to be easily shaped into diverse structures like scaffolds, films, and fibers. However, its inherent low biodegradability limits its applicability for tissue engineering. On the other hand, magnesium, a biocompatible metal known for its good biodegradability and osteoconductivity, is well-suited for bone tissue engineering. In this study, we fabricated and characterized a composite material of Mg/PLA with 5, 10, and 15 wt%Mg alloy (AZ61), which was subsequently 3D printed. The incorporation of Mg particles into PLA matrix offers a solution to overcome the low biodegradation limitations typically associated with the PLA. Moreover, it helps counteract the negative consequences related to the rapid degradation of Mg, such as alkalinization and excessive release of H2. Additionally, the change in pH values and changes in mass during in vitro degradation indicated that the addition of Mg effectively counteracted the acidic byproducts generated by PLA. Furthermore, X-Ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) spectroscopy were utilized to investigate the degradation of the scaffolds, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare and contrast the thermal properties of the composites. Our findings demonstrate that the addition of Mg significantly influences the thermal properties of PLA and notably accelerates its degradation, in addition to its noticeable influence on cell adhesion.
AB - Polylactic acid (PLA)/Magnesium (Mg)-based composites exhibit great potential for applications in bone regeneration and tissue engineering. PLA is a biodegradable and biocompatible polymer, that has the ability to be easily shaped into diverse structures like scaffolds, films, and fibers. However, its inherent low biodegradability limits its applicability for tissue engineering. On the other hand, magnesium, a biocompatible metal known for its good biodegradability and osteoconductivity, is well-suited for bone tissue engineering. In this study, we fabricated and characterized a composite material of Mg/PLA with 5, 10, and 15 wt%Mg alloy (AZ61), which was subsequently 3D printed. The incorporation of Mg particles into PLA matrix offers a solution to overcome the low biodegradation limitations typically associated with the PLA. Moreover, it helps counteract the negative consequences related to the rapid degradation of Mg, such as alkalinization and excessive release of H2. Additionally, the change in pH values and changes in mass during in vitro degradation indicated that the addition of Mg effectively counteracted the acidic byproducts generated by PLA. Furthermore, X-Ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) spectroscopy were utilized to investigate the degradation of the scaffolds, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare and contrast the thermal properties of the composites. Our findings demonstrate that the addition of Mg significantly influences the thermal properties of PLA and notably accelerates its degradation, in addition to its noticeable influence on cell adhesion.
KW - 3D printing
KW - Additive manufacturing
KW - Biodegradation
KW - PLA/Mg composite
UR - http://www.scopus.com/inward/record.url?scp=85167836070&partnerID=8YFLogxK
U2 - 10.1016/j.bprint.2023.e00302
DO - 10.1016/j.bprint.2023.e00302
M3 - Article
AN - SCOPUS:85167836070
SN - 2405-8866
VL - 35
JO - Bioprinting
JF - Bioprinting
M1 - e00302
ER -