Developmental expression profiles of Celsr (Flamingo) genes in the mouse

F. Tissir; O. De-Backer; A. M. Goffinet; C. Lambert de Rouvroit

doi:10.1016/S0925-4773(01)00623-2

Developmental expression profiles of Celsr (Flamingo) genes in the mouse

F. Tissir, O. De-Backer, A. M. Goffinet, C. Lambert de Rouvroit

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Mechanisms of Development
Volume	112
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(01)00623-2
Publication status	Published - 2002
Externally published	Yes

Keywords

Brain development
Cadherin
Cerebral cortex
Flamingo
Frizzled
G-protein coupled receptor
Genomic structure
In situ hybridization

Access to Document

10.1016/S0925-4773(01)00623-2

Cite this

@article{c92c89012caa48a2b120c81597d4493f,

title = "Developmental expression profiles of Celsr (Flamingo) genes in the mouse",

abstract = "Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.",

keywords = "Brain development, Cadherin, Cerebral cortex, Flamingo, Frizzled, G-protein coupled receptor, Genomic structure, In situ hybridization",

author = "F. Tissir and O. De-Backer and Goffinet, {A. M.} and {Lambert de Rouvroit}, C.",

year = "2002",

doi = "10.1016/S0925-4773(01)00623-2",

language = "English",

volume = "112",

pages = "157--160",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Developmental expression profiles of Celsr (Flamingo) genes in the mouse

AU - Tissir, F.

AU - De-Backer, O.

AU - Goffinet, A. M.

AU - Lambert de Rouvroit, C.

PY - 2002

Y1 - 2002

N2 - Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.

AB - Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus. The Drosophila Fmi gene regulates epithelial planar cell polarity and dendritic field deployment. The three Flamingo gene orthologs in man and rodents are named, respectively, CELSR1-3 and Celsr1-3. Celsr1 and 2 are expressed during early development, in the brain and epithelia. In this report, we characterized further Celsr genes in the mouse, and examined their developmental pattern of expression. Each Celsr is expressed prominently in the developing brain following a specific pattern, suggesting that they serve distinct functions.

KW - Brain development

KW - Cadherin

KW - Cerebral cortex

KW - Flamingo

KW - Frizzled

KW - G-protein coupled receptor

KW - Genomic structure

KW - In situ hybridization

UR - http://www.scopus.com/inward/record.url?scp=0036178666&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(01)00623-2

DO - 10.1016/S0925-4773(01)00623-2

M3 - Article

C2 - 11850187

AN - SCOPUS:0036178666

SN - 0925-4773

VL - 112

SP - 157

EP - 160

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1-2

ER -

Developmental expression profiles of Celsr (Flamingo) genes in the mouse

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this