DNA micelles as nanoreactors: Efficient DNA functionalization with hydrophobic organic molecules

Tuan Trinh; Pongphak Chidchob; Hassan S. Bazzi; Hanadi F. Sleiman

doi:10.1039/c6cc04970b

DNA micelles as nanoreactors: Efficient DNA functionalization with hydrophobic organic molecules

Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi, Hanadi F. Sleiman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

Original language	English
Pages (from-to)	10914-10917
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	72
DOIs	https://doi.org/10.1039/c6cc04970b
Publication status	Published - 2016
Externally published	Yes

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10.1039/c6cc04970b

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abstract = "We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.",

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AU - Trinh, Tuan

AU - Chidchob, Pongphak

AU - Bazzi, Hassan S.

AU - Sleiman, Hanadi F.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

AB - We report a micelle-templated method to enhance the reactivity of DNA with highly hydrophobic molecules. Lipids, chromophores and polymers can be conjugated to DNA in high yield and under mild conditions. This method expands the range of DNA-templated reactions for DNA-encoded libraries, oligonucleotide and drug delivery, nanopore mimetics and DNA nanotechnology.

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SN - 1359-7345

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EP - 10917

JO - Chemical Communications

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ER -

DNA micelles as nanoreactors: Efficient DNA functionalization with hydrophobic organic molecules

Abstract

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