Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors

Myoung Goo Kim, Ulrich Strych, Kurt Krause, Michael Benedik, Harold Kohn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

Original languageEnglish
Pages (from-to)130-138
Number of pages9
JournalMedicinal Chemistry Research
Volume12
Issue number3
Publication statusPublished - 2003
Externally publishedYes

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