Abstract
A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.
Original language | English |
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Pages (from-to) | 130-138 |
Number of pages | 9 |
Journal | Medicinal Chemistry Research |
Volume | 12 |
Issue number | 3 |
Publication status | Published - 2003 |
Externally published | Yes |