TY - JOUR
T1 - Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis
AU - Lian, Shu
AU - Li, Wulin
AU - Zhong, Chunlian
AU - Li, Ye
AU - Wu, Changhui
AU - Zhang, Kun
AU - Lin, Jiangfei
AU - Wang, Weiyu
AU - Katanaev, Vladimir
AU - Xie, Xiaodong
AU - Jia, Lee
N1 - Publisher Copyright:
Copyright © 2023, the Chinese Medical Association.
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Background: Ganoderma lucidum (G. lucidum) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients. However, the mechanisms and adjuvant therapeutic effects of G. lucidum in cancer treatment remain unclear. Methods: In this work, G. lucidum spore oil (GanoOil), a newly developed oily G. lucidum spore extract was used to investigate the mechanisms and adjuvant therapeutic effects of GanoOil in conjunction with the chemotherapeutic drug cyclophosphamide (CTX) for preventing breast cancer metastasis. Results: In the model of lung metastasis, orally administered GanoOil increased the population of CD8+ T cells and interleukin (IL)-6 cytokine levels in mouse blood, whereas also enhancing the activity of natural killer cells in the spleen. Furthermore, the combination of GanoOil and CTX effectively suppressed the lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced the ratio of lung and spleen weight to body weight in mice. Moreover, high concentrations of GanoOil exhibited no significant toxicity or side effects in both in vitro and in vivo experiments. Conclusion: In conclusion, GanoOil is a safe drug that can enhance immune activity in mice to achieve therapeutic effects on cancer, and can also synergistically inhibit tumor metastasis with CTX.
AB - Background: Ganoderma lucidum (G. lucidum) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients. However, the mechanisms and adjuvant therapeutic effects of G. lucidum in cancer treatment remain unclear. Methods: In this work, G. lucidum spore oil (GanoOil), a newly developed oily G. lucidum spore extract was used to investigate the mechanisms and adjuvant therapeutic effects of GanoOil in conjunction with the chemotherapeutic drug cyclophosphamide (CTX) for preventing breast cancer metastasis. Results: In the model of lung metastasis, orally administered GanoOil increased the population of CD8+ T cells and interleukin (IL)-6 cytokine levels in mouse blood, whereas also enhancing the activity of natural killer cells in the spleen. Furthermore, the combination of GanoOil and CTX effectively suppressed the lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced the ratio of lung and spleen weight to body weight in mice. Moreover, high concentrations of GanoOil exhibited no significant toxicity or side effects in both in vitro and in vivo experiments. Conclusion: In conclusion, GanoOil is a safe drug that can enhance immune activity in mice to achieve therapeutic effects on cancer, and can also synergistically inhibit tumor metastasis with CTX.
KW - Cyclophosphamide
KW - Il-6
KW - Natural killer cells
KW - Spleen
KW - Spore
UR - http://www.scopus.com/inward/record.url?scp=85186705805&partnerID=8YFLogxK
U2 - 10.1097/JCMA.0000000000001038
DO - 10.1097/JCMA.0000000000001038
M3 - Article
C2 - 38109372
AN - SCOPUS:85186705805
SN - 1726-4901
VL - 87
SP - 305
EP - 313
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 3
ER -