@inproceedings{f597388c54c546fb9156b7b07158eb2c,
title = "Identification of cancer drug sensitivity biomarkers",
abstract = "Anti-cancer therapies have different responses to different patients. There is a need to identify biomarkers for effectiveness of drugs beside the biomarkers for the diseases like cancer to advance the field personalized medicine. We have used a panel of cancer cell lines from Genomics of Drug Sensitivity in Cancer (GDSC) to capture the sensitivity of drugs. By combining the genetic information such as mutations, copy number variations and gene expression levels from Catalogue of Somatic Mutations in Cancer (COSMIC) and The Cancer Genome ATLAS (TCGA) for the afore mentioned cell lines, we are able to identify genomic features associated with the sensitivity of the drugs.",
keywords = "association analysis, biomarkers, cancer, drug sensitivity, genomics, statistical analysis",
author = "Ehsan Ullah and Raghvendra Mall and Halima Bensmail and Reda Rawi and Saila Shama and Muftah, {Nooral Al} and Thmpson, {Ian Richard}",
note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 ; Conference date: 13-11-2017 Through 16-11-2017",
year = "2017",
month = dec,
day = "15",
doi = "10.1109/BIBM.2017.8218043",
language = "English",
series = "Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2322--2324",
editor = "Illhoi Yoo and Zheng, {Jane Huiru} and Yang Gong and Hu, {Xiaohua Tony} and Chi-Ren Shyu and Yana Bromberg and Jean Gao and Dmitry Korkin",
booktitle = "Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017",
address = "United States",
}