Insight into the Interactions of Amyloid β-Sheets with Graphene Flakes: Scrutinizing the Role of Aromatic Residues in Amyloids that Interact with Graphene

Dragana M. Božinovski, Predrag V. Petrović, Milivoj R. Belić, Snežana D. Zarić*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The interaction of amyloid β-sheet segments with graphene-flake models is investigated by using DFT calculations. The structure of β-sheets of selected amyloid segments is based on crystal structures obtained from the Protein Data Bank. Our study, based on DFT calculations for model systems, indicates that the interaction in amyloid–graphene aggregates can be stronger than the interaction in the respective amyloid–amyloid aggregates. The results also indicate an important specific role of aromatic sidechains in amyloid–graphene interactions. This work confirms recent experimental evidence that graphene and its modifications inhibit the aggregation of β-amyloid peptides.

Original languageEnglish
Pages (from-to)1226-1233
Number of pages8
JournalChemPhysChem
Volume19
Issue number10
DOIs
Publication statusPublished - 22 May 2018
Externally publishedYes

Keywords

  • aggregation
  • amyloid beta-peptides
  • density functional calculations
  • graphene
  • noncovalent interactions

Fingerprint

Dive into the research topics of 'Insight into the Interactions of Amyloid β-Sheets with Graphene Flakes: Scrutinizing the Role of Aromatic Residues in Amyloids that Interact with Graphene'. Together they form a unique fingerprint.

Cite this