Instrumentation and Analytical Methods

J. H.T. Luong; K. A. Mahmoud; K. B. Male

doi:10.1016/B978-0-08-088504-9.00139-2

Instrumentation and Analytical Methods

J. H.T. Luong^*, K. A. Mahmoud, K. B. Male

^*Corresponding author for this work

National Research Council of Canada

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Citations (Scopus)

Abstract

Application of sensor systems in bioprocesses is not as widespread as expected due to stringent requirements of aseptic conditions, high number of analytes, rapid response, and lengthy signal stability. Advances in sensor technology, analytical science, and microelectronics may pave the way to the development of various in situ and ex situ sensors for monitoring industrial bioprocesses. However, full automation of flow injection, analysis, and sampling procedures, and improved reliability and sensitivity of such sensors, as well as miniaturization, are still much needed for use in complex industrial culture media. This article gives an overview of diverse sensing schemes and the ongoing developments in the field of bioprocess monitoring of physical parameters, biomass and viability, and chemical parameters.

Original language	English
Title of host publication	Engineering Fundamentals of Biotechnology
Publisher	Elsevier Inc.
Pages	829-838
Number of pages	10
Volume	2
ISBN (Electronic)	9780080885049
ISBN (Print)	9780444533524
DOIs	https://doi.org/10.1016/B978-0-08-088504-9.00139-2
Publication status	Published - 9 Sept 2011
Externally published	Yes

Keywords

Biosensors
Calorimetry
Cell mass
In situ
Infrared spectroscopy
NADH
Offline
Online
Raman spectroscopy

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10.1016/B978-0-08-088504-9.00139-2

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AU - Mahmoud, K. A.

AU - Male, K. B.

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KW - Biosensors

KW - Calorimetry

KW - Cell mass

KW - In situ

KW - Infrared spectroscopy

KW - NADH

KW - Offline

KW - Online

KW - Raman spectroscopy

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BT - Engineering Fundamentals of Biotechnology

PB - Elsevier Inc.

ER -

Instrumentation and Analytical Methods

Abstract

Keywords

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