Integrative 1H-NMR-based metabolomic profiling to identify type-2 diabetes biomarkers: An application to a population of Qatar

Ehsan Ullah; M Shahzad; Reda Rawi; Mohammed Dehbi; Karsten Suhre; Mohamed Salim; D. Mook; Halima  Bensmail

doi:10.4172/2153-0769.1000136

Integrative 1H-NMR-based metabolomic profiling to identify type-2 diabetes biomarkers: An application to a population of Qatar

Ehsan Ullah, M Shahzad, Reda Rawi, Mohammed Dehbi, Karsten Suhre, Mohamed Salim, D. Mook, Halima Bensmail

Qatar Computing Research Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Diabetes is a leading health problem in the developed world. The recent surge of wealth in Qatar has made it one of the most vulnerable nations to diabetes and related diseases. Recent technological advances in 1 H Nuclear Magnetic
Resonance (NMR) spectroscopy techniques for metabolomics profiling offer a great opportunity for biomarkers discovery. Using this technology, we present in this study, an integrative approach to discover new metabolites and possibly new biomarkers. We performed an integrative analysis of 1 H NMR spectras measured in urine, from 348 participants of the Qatar Metabolomics Study on Diabetes (QM- Diab). Our analyses revealed several metabolites that correlate with diabetes and identified specific metabolites affected by anti- diabetes medication, which constraints differentiation between diabetic and control patients.

Original language	English
Number of pages	8
Journal	Metabolomics
DOIs	https://doi.org/10.4172/2153-0769.1000136
Publication status	Published - 16 Jan 2015

Keywords

H-NMR
Metabolomics
Biomarkers
Diabetes
PCA
ADMM

Access to Document

10.4172/2153-0769.1000136

https://scholar.google.com/citations?view_op=view_citation&hl=en&user=Nlf0C2EAAAAJ&pagesize=100&citation_for_view=Nlf0C2EAAAAJ:_Qo2XoVZTnwC

Cite this

@article{2f0b670dd8524a24a3a345d1b055b617,

title = "Integrative 1H-NMR-based metabolomic profiling to identify type-2 diabetes biomarkers: An application to a population of Qatar",

abstract = "Diabetes is a leading health problem in the developed world. The recent surge of wealth in Qatar has made it one of the most vulnerable nations to diabetes and related diseases. Recent technological advances in 1 H Nuclear MagneticResonance (NMR) spectroscopy techniques for metabolomics profiling offer a great opportunity for biomarkers discovery. Using this technology, we present in this study, an integrative approach to discover new metabolites and possibly new biomarkers. We performed an integrative analysis of 1 H NMR spectras measured in urine, from 348 participants of the Qatar Metabolomics Study on Diabetes (QM- Diab). Our analyses revealed several metabolites that correlate with diabetes and identified specific metabolites affected by anti- diabetes medication, which constraints differentiation between diabetic and control patients.",

keywords = "H-NMR, Metabolomics, Biomarkers, Diabetes, PCA, ADMM",

author = "Ehsan Ullah and M Shahzad and Reda Rawi and Mohammed Dehbi and Karsten Suhre and Mohamed Salim and D. Mook and Halima Bensmail",

year = "2015",

month = jan,

day = "16",

doi = "10.4172/2153-0769.1000136",

language = "English",

journal = "Metabolomics",

issn = "1573-3882",

publisher = "Springer",

}

TY - JOUR

T1 - Integrative 1H-NMR-based metabolomic profiling to identify type-2 diabetes biomarkers: An application to a population of Qatar

AU - Ullah, Ehsan

AU - Shahzad, M

AU - Rawi, Reda

AU - Dehbi, Mohammed

AU - Suhre, Karsten

AU - Salim, Mohamed

AU - Mook, D.

AU - Bensmail, Halima

PY - 2015/1/16

Y1 - 2015/1/16

N2 - Diabetes is a leading health problem in the developed world. The recent surge of wealth in Qatar has made it one of the most vulnerable nations to diabetes and related diseases. Recent technological advances in 1 H Nuclear MagneticResonance (NMR) spectroscopy techniques for metabolomics profiling offer a great opportunity for biomarkers discovery. Using this technology, we present in this study, an integrative approach to discover new metabolites and possibly new biomarkers. We performed an integrative analysis of 1 H NMR spectras measured in urine, from 348 participants of the Qatar Metabolomics Study on Diabetes (QM- Diab). Our analyses revealed several metabolites that correlate with diabetes and identified specific metabolites affected by anti- diabetes medication, which constraints differentiation between diabetic and control patients.

AB - Diabetes is a leading health problem in the developed world. The recent surge of wealth in Qatar has made it one of the most vulnerable nations to diabetes and related diseases. Recent technological advances in 1 H Nuclear MagneticResonance (NMR) spectroscopy techniques for metabolomics profiling offer a great opportunity for biomarkers discovery. Using this technology, we present in this study, an integrative approach to discover new metabolites and possibly new biomarkers. We performed an integrative analysis of 1 H NMR spectras measured in urine, from 348 participants of the Qatar Metabolomics Study on Diabetes (QM- Diab). Our analyses revealed several metabolites that correlate with diabetes and identified specific metabolites affected by anti- diabetes medication, which constraints differentiation between diabetic and control patients.

KW - H-NMR

KW - Metabolomics

KW - Biomarkers

KW - Diabetes

KW - PCA

KW - ADMM

U2 - 10.4172/2153-0769.1000136

DO - 10.4172/2153-0769.1000136

M3 - Article

SN - 1573-3882

JO - Metabolomics

JF - Metabolomics

ER -

Integrative 1H-NMR-based metabolomic profiling to identify type-2 diabetes biomarkers: An application to a population of Qatar

Abstract

Keywords

Access to Document

Fingerprint

Cite this