TY - GEN
T1 - Intervention in biological phenomena modeled by S-systems
T2 - A model predictive control approach
AU - Meskin, N.
AU - Nounou, H.
AU - Nounou, M.
AU - Datta, A.
AU - Dougherty, E. R.
PY - 2011
Y1 - 2011
N2 - Recent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme.
AB - Recent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme.
UR - http://www.scopus.com/inward/record.url?scp=80053141962&partnerID=8YFLogxK
U2 - 10.1109/acc.2011.5990875
DO - 10.1109/acc.2011.5990875
M3 - Conference contribution
AN - SCOPUS:80053141962
SN - 9781457700804
T3 - Proceedings of the American Control Conference
SP - 3519
EP - 3523
BT - Proceedings of the 2011 American Control Conference, ACC 2011
PB - Institute of Electrical and Electronics Engineers Inc.
ER -