KIR genotype distribution among symptomatic patients with and without Helicobacter pylori infection: Is there any role for the B haplotype?

Rami Mahfouz*, R. Hoteit, N. El Hajj, D. Shammaa, A. I. Sharara

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Contact of peripheral blood lymphocytes with Helicobacter pylori was proved to induce non- major histocompatibility complex-restricted cytotoxicity and natural killer cells are thought to play an important role in the immunity against H. pylori.

Aims: In this research, we investigated any possible association between killer immunoglobulin-like receptors (KIR) genotypes and H. pylori infection.

Methods: KIR genotype was analysed in 101 Lebanese symptomatic patients (51 H. pylori positive and 50 H. pylori-negative) using the KIR Genotyping SSP kit.

Results: Among the H. pylori-positive patients, the AA, AB and BB genotypical frequencies were, respectively, 43.14%, 41.18% and 15.68% with an A:B ratio of 1.76:1. The AA, AB and BB genotypes frequencies for H. pylori-negative individuals were 18%, 62% and 20%, respectively, with an A:B ratio of 0.96:1. No significant difference between patients and controls was detected.

Conclusions: We noticed a reduced distribution of A haplotype among the 'H. pylori-negative' patients as compared with the "H. pylori-positive" group. This is the first study in the international literature that targets the correlation between KIR genotypes and H. pylori.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalJournal of Clinical Pathology
Volume68
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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