Linezolid toxicity and mitochondrial susceptibility: A novel neurological complication in a lebanese patient

Ossama K. Abou Hassan, Mohamad Karnib, Riyad El-Khoury, Georges Nemer, Mamdouha Ahdab-Barmada, Pierre BouKhalil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The recent rise in the use of linezolid to treat a variety of resistant pathogens has uncovered many side effects. Some patients develop lactic acidosis, myelosuppression, optic or peripheral neuropathies, and myopathies. We evaluated an elderly patient who presented to the Emergency Room with linezolid toxicity and a novel neurologic complication characterized by bilateral globi pallidi necrosis. Mitochondrial ribosome inhibition was described to be the predisposing factor. The patient belongs to the mitochondrial J1 haplotype known to be associated with side effects of the drug. We recommend based on the molecular profile of the illness pretreatment considerations and complication management.

Original languageEnglish
Article number325
JournalFrontiers in Pharmacology
Volume7
Issue numberSEP
DOIs
Publication statusPublished - 20 Sept 2016
Externally publishedYes

Keywords

  • Globus pallidus
  • J1 haplogroup
  • Linezolid
  • Mitochondria
  • Toxicity

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