Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus

Vojislav Jovanović; Nurhuda Abdul Aziz; Yan Ting Lim; Amanda Ng Ai Poh; Sherlynn Jin Hui Chan; Eliza Ho Xin Pei; Fei Chuin Lew; Guanghou Shui; Andrew M. Jenner; Li Bowen; Eoin F. McKinney; Paul A. Lyons; Michael D. Kemeny; Kenneth G.C. Smith; Markus R. Wenk; Paul A. MacAry

doi:10.1371/journal.pone.0055639

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus

Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M. Jenner, Li Bowen, Eoin F. McKinney, Paul A. Lyons, Michael D. Kemeny, Kenneth G.C. Smith, Markus R. Wenk, Paul A. MacAry

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17 Citations (Scopus)

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.

Original language	English
Article number	e55639
Journal	PLoS ONE
Volume	8
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0055639
Publication status	Published - 7 Feb 2013
Externally published	Yes

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Jovanović, V., Abdul Aziz, N., Lim, Y. T., Ng Ai Poh, A., Jin Hui Chan, S., Ho Xin Pei, E., Lew, F. C., Shui, G., Jenner, A. M., Bowen, L., McKinney, E. F., Lyons, P. A., Kemeny, M. D., Smith, K. G. C., Wenk, M. R., & MacAry, P. A. (2013). Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus. PLoS ONE, 8(2), Article e55639. https://doi.org/10.1371/journal.pone.0055639

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title = "Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus",

abstract = "Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.",

author = "Vojislav Jovanovi{\'c} and {Abdul Aziz}, Nurhuda and Lim, {Yan Ting} and {Ng Ai Poh}, Amanda and {Jin Hui Chan}, Sherlynn and {Ho Xin Pei}, Eliza and Lew, {Fei Chuin} and Guanghou Shui and Jenner, {Andrew M.} and Li Bowen and McKinney, {Eoin F.} and Lyons, {Paul A.} and Kemeny, {Michael D.} and Smith, {Kenneth G.C.} and Wenk, {Markus R.} and MacAry, {Paul A.}",

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Jovanović, V, Abdul Aziz, N, Lim, YT, Ng Ai Poh, A, Jin Hui Chan, S, Ho Xin Pei, E, Lew, FC, Shui, G, Jenner, AM, Bowen, L, McKinney, EF, Lyons, PA, Kemeny, MD, Smith, KGC, Wenk, MR & MacAry, PA 2013, 'Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus', PLoS ONE, vol. 8, no. 2, e55639. https://doi.org/10.1371/journal.pone.0055639

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T1 - Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus

AU - Jovanović, Vojislav

AU - Abdul Aziz, Nurhuda

AU - Lim, Yan Ting

AU - Ng Ai Poh, Amanda

AU - Jin Hui Chan, Sherlynn

AU - Ho Xin Pei, Eliza

AU - Lew, Fei Chuin

AU - Shui, Guanghou

AU - Jenner, Andrew M.

AU - Bowen, Li

AU - McKinney, Eoin F.

AU - Lyons, Paul A.

AU - Kemeny, Michael D.

AU - Smith, Kenneth G.C.

AU - Wenk, Markus R.

AU - MacAry, Paul A.

PY - 2013/2/7

Y1 - 2013/2/7

N2 - Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.

AB - Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main contributing factors to the pathology of SLE is the accumulation and impaired clearance of immune complexes of which the principle components are host auto-antigens and antibodies. The contribution of host lipids to the formation of these autoimmune complexes remains poorly defined. The aim of the present study was to identify and analyze candidate lipid autoantigens and their corresponding anti-lipid antibody responses in a well-defined SLE patient cohort using a combination of immunological and biophysical techniques. Disease monitoring in the SLE cohort was undertaken with serial British Isles Lupus Assessment Group (BILAG) scoring. Correlations between specific lipid/anti-lipid responses were investigated as disease activity developed from active flares to quiescent during a follow up period. We report a significant negative correlation between anti-lipid antibodies for 24S-hydroxycholesterol, cardiolipin and phosphatidylserine with SLE disease activity. Taken together, these data suggest that lipid autoantigens represent a new family of biomarkers that can be employed to monitor disease activity plus the efficacy of therapeutic intervention in SLE.

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U2 - 10.1371/journal.pone.0055639

DO - 10.1371/journal.pone.0055639

M3 - Article

C2 - 23409013

AN - SCOPUS:84873576189

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 2

M1 - e55639

ER -

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus

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