LipidGO: Database for lipid-related GO terms and applications

Mengyuan Fan; Hong Sang Low; Hufeng Zhou; Markus R. Wenk; Limsoon Wong

doi:10.1093/bioinformatics/btt689

LipidGO: Database for lipid-related GO terms and applications

Mengyuan Fan, Hong Sang Low, Hufeng Zhou, Markus R. Wenk, Limsoon Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Motivation: Lipid, an essential class of biomolecules, is receiving increasing attention in the research community, especially with the development of analytical technique like mass spectrometry. Gene Ontology (GO) is the de facto standard function annotation scheme for gene products. Identification of both explicit and implicit lipid-related GO terms will help lipid research in many ways, e.g. assigning lipid function in protein function prediction.Results: We have constructed a Web site 'LipidGO' that facilitates browsing and searching lipid-related GO terms. An expandable hierarchical GO tree is constructed that allows users to find lipid-related GO terms easily. To support large-scale analysis, a user is able to upload a list of gene products or a list of GO terms to find out which of them is lipid related. Finally, we demonstrate the usefulness of 'LipidGO' by two applications: (i) identifying lipid-related gene products in model organisms and (ii) discovering potential novel lipid-related molecular functions

Original language	English
Pages (from-to)	1043-1044
Number of pages	2
Journal	Bioinformatics
Volume	30
Issue number	7
DOIs	https://doi.org/10.1093/bioinformatics/btt689
Publication status	Published - 1 Apr 2014
Externally published	Yes

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title = "LipidGO: Database for lipid-related GO terms and applications",

abstract = "Motivation: Lipid, an essential class of biomolecules, is receiving increasing attention in the research community, especially with the development of analytical technique like mass spectrometry. Gene Ontology (GO) is the de facto standard function annotation scheme for gene products. Identification of both explicit and implicit lipid-related GO terms will help lipid research in many ways, e.g. assigning lipid function in protein function prediction.Results: We have constructed a Web site 'LipidGO' that facilitates browsing and searching lipid-related GO terms. An expandable hierarchical GO tree is constructed that allows users to find lipid-related GO terms easily. To support large-scale analysis, a user is able to upload a list of gene products or a list of GO terms to find out which of them is lipid related. Finally, we demonstrate the usefulness of 'LipidGO' by two applications: (i) identifying lipid-related gene products in model organisms and (ii) discovering potential novel lipid-related molecular functions",

author = "Mengyuan Fan and Low, {Hong Sang} and Hufeng Zhou and Wenk, {Markus R.} and Limsoon Wong",

year = "2014",

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doi = "10.1093/bioinformatics/btt689",

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volume = "30",

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journal = "Bioinformatics",

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T2 - Database for lipid-related GO terms and applications

AU - Fan, Mengyuan

AU - Low, Hong Sang

AU - Zhou, Hufeng

AU - Wenk, Markus R.

AU - Wong, Limsoon

PY - 2014/4/1

Y1 - 2014/4/1

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AB - Motivation: Lipid, an essential class of biomolecules, is receiving increasing attention in the research community, especially with the development of analytical technique like mass spectrometry. Gene Ontology (GO) is the de facto standard function annotation scheme for gene products. Identification of both explicit and implicit lipid-related GO terms will help lipid research in many ways, e.g. assigning lipid function in protein function prediction.Results: We have constructed a Web site 'LipidGO' that facilitates browsing and searching lipid-related GO terms. An expandable hierarchical GO tree is constructed that allows users to find lipid-related GO terms easily. To support large-scale analysis, a user is able to upload a list of gene products or a list of GO terms to find out which of them is lipid related. Finally, we demonstrate the usefulness of 'LipidGO' by two applications: (i) identifying lipid-related gene products in model organisms and (ii) discovering potential novel lipid-related molecular functions

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LipidGO: Database for lipid-related GO terms and applications

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