TY - GEN
T1 - Lipidomics as a diagnostic and research tool
AU - Fernandis, Aaron Z.
AU - Wenk, Markus
PY - 2010
Y1 - 2010
N2 - Lipids play an important role in signaling mechanisms, regulation of protein function and control of a wide variety of cellular responses. As these lipids are important regulators their levels are tightly controlled and fine tuned both spatially as well as temporally. An imbalance in these lipids, in particular those involved in cell signaling, could lead to various pathological disorders. Thus these lipids and their effectors can serve as biomarkers. Indeed, cardiovascular diseases, obesity, neurological disorders, as well as infectious diseases have been directly implicated with aberrant lipid metabolism. This indicates that careful inspection of lipid level using metabolic profiling could help in clinical diagnostics of these pathologies.
AB - Lipids play an important role in signaling mechanisms, regulation of protein function and control of a wide variety of cellular responses. As these lipids are important regulators their levels are tightly controlled and fine tuned both spatially as well as temporally. An imbalance in these lipids, in particular those involved in cell signaling, could lead to various pathological disorders. Thus these lipids and their effectors can serve as biomarkers. Indeed, cardiovascular diseases, obesity, neurological disorders, as well as infectious diseases have been directly implicated with aberrant lipid metabolism. This indicates that careful inspection of lipid level using metabolic profiling could help in clinical diagnostics of these pathologies.
UR - http://www.scopus.com/inward/record.url?scp=79955703136&partnerID=8YFLogxK
U2 - 10.1109/ICSMB.2010.5735332
DO - 10.1109/ICSMB.2010.5735332
M3 - Conference contribution
AN - SCOPUS:79955703136
SN - 9781612840383
T3 - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
SP - 4
EP - 5
BT - International Conference on Systems in Medicine and Biology, ICSMB 2010 - Proceedings
T2 - International Conference on Systems in Medicine and Biology, ICSMB 2010
Y2 - 16 December 2010 through 18 December 2010
ER -