Loaded paraquaton polymeric nanocapsules and evaluation for cardiotoxicity in Wistar rats

Ali Jafari, Efat Nazari, Mansour Ghaderpoori*, Marzieh Rashidipour, Afshin Nazari, Farzaneh Chehelcheraghi, Bahram Kamarehie, Reza Rezaee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Present work was conducted to prepare and evaluate, loaded paraquat nano-hydrogels using chitosan, sodium polytriphosphate, and xanthan via ionic gelification method. The fabricated L-PQ formulations were analyzed for surface morphology and functional groups using SEM and FTIR, respectively. The stability of the synthesized nanoparticle was, also, analyzed in terms of diameter size, zeta potential, dispersion index, and pH. Furthermore, the cardiotoxicity effects of the synthesized nanogels were investigated on Wistar rats in terms of enzymatic activity, echocardiographic, and histological analysis. The proper stability of the prepared formulation was also confirmed by diameter size, zeta potential, dispersion index, and pH. The efficiency of encapsulation was about 90±3.2% and the release of PQ in the loaded nanogel was about 90±2.3%. A decrease in ST (shortening time) segment by formulated PQ, either in peritoneal or gavage exposure pathway, indicates the effectiveness of the capsule layer against the penetration of toxin into the body.

Original languageEnglish
Pages (from-to)1284-1298
Number of pages15
JournalInternational Journal of Environmental Health Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2024
Externally publishedYes

Keywords

  • Cardiotoxicity
  • Chitosan
  • Herbicide
  • Nanoparticle
  • Paraquat

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