TY - JOUR
T1 - Loaded paraquaton polymeric nanocapsules and evaluation for cardiotoxicity in Wistar rats
AU - Jafari, Ali
AU - Nazari, Efat
AU - Ghaderpoori, Mansour
AU - Rashidipour, Marzieh
AU - Nazari, Afshin
AU - Chehelcheraghi, Farzaneh
AU - Kamarehie, Bahram
AU - Rezaee, Reza
N1 - Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024
Y1 - 2024
N2 - Present work was conducted to prepare and evaluate, loaded paraquat nano-hydrogels using chitosan, sodium polytriphosphate, and xanthan via ionic gelification method. The fabricated L-PQ formulations were analyzed for surface morphology and functional groups using SEM and FTIR, respectively. The stability of the synthesized nanoparticle was, also, analyzed in terms of diameter size, zeta potential, dispersion index, and pH. Furthermore, the cardiotoxicity effects of the synthesized nanogels were investigated on Wistar rats in terms of enzymatic activity, echocardiographic, and histological analysis. The proper stability of the prepared formulation was also confirmed by diameter size, zeta potential, dispersion index, and pH. The efficiency of encapsulation was about 90±3.2% and the release of PQ in the loaded nanogel was about 90±2.3%. A decrease in ST (shortening time) segment by formulated PQ, either in peritoneal or gavage exposure pathway, indicates the effectiveness of the capsule layer against the penetration of toxin into the body.
AB - Present work was conducted to prepare and evaluate, loaded paraquat nano-hydrogels using chitosan, sodium polytriphosphate, and xanthan via ionic gelification method. The fabricated L-PQ formulations were analyzed for surface morphology and functional groups using SEM and FTIR, respectively. The stability of the synthesized nanoparticle was, also, analyzed in terms of diameter size, zeta potential, dispersion index, and pH. Furthermore, the cardiotoxicity effects of the synthesized nanogels were investigated on Wistar rats in terms of enzymatic activity, echocardiographic, and histological analysis. The proper stability of the prepared formulation was also confirmed by diameter size, zeta potential, dispersion index, and pH. The efficiency of encapsulation was about 90±3.2% and the release of PQ in the loaded nanogel was about 90±2.3%. A decrease in ST (shortening time) segment by formulated PQ, either in peritoneal or gavage exposure pathway, indicates the effectiveness of the capsule layer against the penetration of toxin into the body.
KW - Cardiotoxicity
KW - Chitosan
KW - Herbicide
KW - Nanoparticle
KW - Paraquat
UR - http://www.scopus.com/inward/record.url?scp=85148506733&partnerID=8YFLogxK
U2 - 10.1080/09603123.2023.2181317
DO - 10.1080/09603123.2023.2181317
M3 - Article
C2 - 36800924
AN - SCOPUS:85148506733
SN - 0960-3123
VL - 34
SP - 1284
EP - 1298
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
IS - 3
ER -