Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition

Nilanjan Sanyal; Samsul Alam; Saswati Pradhan; Kaushik Banerjee; Ashim Chowdhury; Md Wasim Aktar

doi:10.1007/s10661-015-4345-5

Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition

Nilanjan Sanyal, Samsul Alam, Saswati Pradhan, Kaushik Banerjee, Ashim Chowdhury, Md Wasim Aktar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Present investigation was carried out using two commercial products Raft (oxadiargyl 6 % EC) and Topstar (oxadiargyl 80 % WP) of Oxadiargyl {5-tert-butyl-3[2,4-dichloro-5-(prop-2-ynyloxy)phenyl]-1,3,4-oxadiazol-2 (3H)-one} to investigate the persistence behavior and metabolism of the herbicide in various aqueous system under different pH condition. Half-life values revealed that alkaline hydrolysis played a dominant role in hydrolytic degradation of this compound. Q-ToF micromass study with the alkaline fractions of oxadiargyl indicated the formation of five metabolites, which was further characterized from their mass fragmentation data. The nature of metabolites formed indicated that heterocyclic oxadiazoline ring cleavage was found to be the main pathway of hydrolytic transformation of oxadiargyl.

Original language	English
Article number	433
Journal	Environmental Monitoring and Assessment
Volume	187
Issue number	7
DOIs	https://doi.org/10.1007/s10661-015-4345-5
Publication status	Published - 17 Jul 2015
Externally published	Yes

Keywords

Buffered water
Metabolic pathway
Oxadiargyl
Persistence
Pseudo-first-order kinetics
pH

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10.1007/s10661-015-4345-5

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title = "Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition",

abstract = "Present investigation was carried out using two commercial products Raft (oxadiargyl 6 % EC) and Topstar (oxadiargyl 80 % WP) of Oxadiargyl {5-tert-butyl-3[2,4-dichloro-5-(prop-2-ynyloxy)phenyl]-1,3,4-oxadiazol-2 (3H)-one} to investigate the persistence behavior and metabolism of the herbicide in various aqueous system under different pH condition. Half-life values revealed that alkaline hydrolysis played a dominant role in hydrolytic degradation of this compound. Q-ToF micromass study with the alkaline fractions of oxadiargyl indicated the formation of five metabolites, which was further characterized from their mass fragmentation data. The nature of metabolites formed indicated that heterocyclic oxadiazoline ring cleavage was found to be the main pathway of hydrolytic transformation of oxadiargyl.",

keywords = "Buffered water, Metabolic pathway, Oxadiargyl, Persistence, Pseudo-first-order kinetics, pH",

author = "Nilanjan Sanyal and Samsul Alam and Saswati Pradhan and Kaushik Banerjee and Ashim Chowdhury and Aktar, {Md Wasim}",

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doi = "10.1007/s10661-015-4345-5",

language = "English",

volume = "187",

journal = "Environmental Monitoring and Assessment",

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Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition. / Sanyal, Nilanjan; Alam, Samsul; Pradhan, Saswati et al.
In: Environmental Monitoring and Assessment, Vol. 187, No. 7, 433, 17.07.2015.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition

AU - Sanyal, Nilanjan

AU - Alam, Samsul

AU - Pradhan, Saswati

AU - Banerjee, Kaushik

AU - Chowdhury, Ashim

AU - Aktar, Md Wasim

PY - 2015/7/17

Y1 - 2015/7/17

N2 - Present investigation was carried out using two commercial products Raft (oxadiargyl 6 % EC) and Topstar (oxadiargyl 80 % WP) of Oxadiargyl {5-tert-butyl-3[2,4-dichloro-5-(prop-2-ynyloxy)phenyl]-1,3,4-oxadiazol-2 (3H)-one} to investigate the persistence behavior and metabolism of the herbicide in various aqueous system under different pH condition. Half-life values revealed that alkaline hydrolysis played a dominant role in hydrolytic degradation of this compound. Q-ToF micromass study with the alkaline fractions of oxadiargyl indicated the formation of five metabolites, which was further characterized from their mass fragmentation data. The nature of metabolites formed indicated that heterocyclic oxadiazoline ring cleavage was found to be the main pathway of hydrolytic transformation of oxadiargyl.

AB - Present investigation was carried out using two commercial products Raft (oxadiargyl 6 % EC) and Topstar (oxadiargyl 80 % WP) of Oxadiargyl {5-tert-butyl-3[2,4-dichloro-5-(prop-2-ynyloxy)phenyl]-1,3,4-oxadiazol-2 (3H)-one} to investigate the persistence behavior and metabolism of the herbicide in various aqueous system under different pH condition. Half-life values revealed that alkaline hydrolysis played a dominant role in hydrolytic degradation of this compound. Q-ToF micromass study with the alkaline fractions of oxadiargyl indicated the formation of five metabolites, which was further characterized from their mass fragmentation data. The nature of metabolites formed indicated that heterocyclic oxadiazoline ring cleavage was found to be the main pathway of hydrolytic transformation of oxadiargyl.

KW - Buffered water

KW - Metabolic pathway

KW - Oxadiargyl

KW - Persistence

KW - Pseudo-first-order kinetics

KW - pH

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SN - 0167-6369

VL - 187

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ER -

Metabolism and dissipation kinetics of a novel protoporphyrinogen IX oxidase herbicide [oxadiargyl] in various buffered aqueous system under laboratory-simulated condition

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Keywords

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