Methods of forming compounds

Dastgir Sarim (Inventor), Al-Shihi Badria (Inventor), Sharif Mohammad (Inventor), Beller Matthias (Inventor), Jackstell Ralf (Inventor)

Research output: Patent

Abstract

A method of forming a compound of Formula (I): the method comprising the steps of (i) providing a compound of Formulae (II), (III) or (IV); wherein R1, R2 and R4 is H or optionally substituted alkyl or phenyl; and R3 is H; and (ii) reacting the compound of Formula (II), (III) or (IV) with CO2 in the presence of a Pd(0) source and a phosphine ligand to form a compound of Formula (I). R1, R2, R3 and R4 are preferably H; particularly the compound of step (i) is 1,3-butadiene. The phosphine ligand is preferably of the formula PR5R6R7, wherein R5, R6 and R7 are independently selected from optionally substituted aryl, linear alkyl, cyclic alkyl, cyclic heteroalkyl or adamantyl; and is preferably tris(2-methoxyphenyl)phosphine (TOMP). The Pd(0) source is preferably selected from Pd(acac)2, Pd(OAc)2, PdCl2(MeCN)2, Pd(dba)2, [PdCl(allyl)]2, Pd2(dba)3 or a Pd(II) complex capable of being reduced in situ to produce a Pd(0) species, in particular Pd(acac)2. The prepared compound of Formula (1) is preferably (E)-2-ethylidenehept-6-en-5-olide. Claims are also directed to a compound of Formula (1) obtained or obtainable via the disclosed method. Methods of converting the compound of Formula (I) to other compounds are also claimed.

Original languageEnglish
Patent numberGB2550876
IPCB01J 31/ 24 A I
Priority date26/05/16
Publication statusPublished - 6 Dec 2017

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