Microelectrode design in mems-based DEP cell filtration devices

Mohammed J. Ahamed; Mohammad A. Rahman

doi:10.1115/nano2005-87049

Microelectrode design in mems-based DEP cell filtration devices

Mohammed J. Ahamed^*, Mohammad A. Rahman

^*Corresponding author for this work

University of Toronto

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle. FEM numerical simulation results were also used to determine 50μm as the optimal circular electrode diameter and 25μm as the optimal gap between electrodes.

Original language	English
Title of host publication	Proceedings of the 4th ASME Integrated Nanosystems Conference
Subtitle of host publication	Design, Synthesis, and Applications
Publisher	American Society of Mechanical Engineers
Pages	7-8
Number of pages	2
ISBN (Print)	0791842088, 9780791842089
DOIs	https://doi.org/10.1115/nano2005-87049
Publication status	Published - 2005
Externally published	Yes
Event	4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications - Berkeley, CA, United States Duration: 14 Sept 2005 → 16 Sept 2005

Publication series

Name	2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications

Conference

Conference	4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications
Country/Territory	United States
City	Berkeley, CA
Period	14/09/05 → 16/09/05

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10.1115/nano2005-87049

Cite this

Ahamed, M. J., & Rahman, M. A. (2005). Microelectrode design in mems-based DEP cell filtration devices. In Proceedings of the 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications (pp. 7-8). (2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications). American Society of Mechanical Engineers. https://doi.org/10.1115/nano2005-87049

Ahamed, Mohammed J. ; Rahman, Mohammad A. / Microelectrode design in mems-based DEP cell filtration devices. Proceedings of the 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications. American Society of Mechanical Engineers, 2005. pp. 7-8 (2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications).

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title = "Microelectrode design in mems-based DEP cell filtration devices",

abstract = "This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle. FEM numerical simulation results were also used to determine 50μm as the optimal circular electrode diameter and 25μm as the optimal gap between electrodes.",

author = "Ahamed, {Mohammed J.} and Rahman, {Mohammad A.}",

year = "2005",

doi = "10.1115/nano2005-87049",

language = "English",

isbn = "0791842088",

series = "2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications",

publisher = "American Society of Mechanical Engineers",

pages = "7--8",

booktitle = "Proceedings of the 4th ASME Integrated Nanosystems Conference",

note = "4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications ; Conference date: 14-09-2005 Through 16-09-2005",

}

Ahamed, MJ & Rahman, MA 2005, Microelectrode design in mems-based DEP cell filtration devices. in Proceedings of the 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications. 2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications, American Society of Mechanical Engineers, pp. 7-8, 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications, Berkeley, CA, United States, 14/09/05. https://doi.org/10.1115/nano2005-87049

Microelectrode design in mems-based DEP cell filtration devices. / Ahamed, Mohammed J.; Rahman, Mohammad A.
Proceedings of the 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications. American Society of Mechanical Engineers, 2005. p. 7-8 (2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle. FEM numerical simulation results were also used to determine 50μm as the optimal circular electrode diameter and 25μm as the optimal gap between electrodes.

AB - This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle. FEM numerical simulation results were also used to determine 50μm as the optimal circular electrode diameter and 25μm as the optimal gap between electrodes.

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DO - 10.1115/nano2005-87049

M3 - Conference contribution

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SN - 9780791842089

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Ahamed MJ, Rahman MA. Microelectrode design in mems-based DEP cell filtration devices. In Proceedings of the 4th ASME Integrated Nanosystems Conference: Design, Synthesis, and Applications. American Society of Mechanical Engineers. 2005. p. 7-8. (2005 Proceedings of the 4th ASME Conference on Integrated Nanosystems: Design, Synthesis, and Applications). doi: 10.1115/nano2005-87049

Microelectrode design in mems-based DEP cell filtration devices

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