Migration speed of Cajal-Retzius cells modulated by vesicular trafficking controls the size of higher-order cortical areas

Melissa Barber, Yoko Arai, Yoshihiro Morishita, Lisa Vigier, Frédéric Causeret, Ugo Borello, Fanny Ledonne, Eva Coppola, Vincent Contremoulins, Frank W. Pfrieger, Fadel Tissir, Subashika Govindan, Denis Jabaudon, Véronique Proux-Gillardeaux, Thierry Galli, Alessandra Pierani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory, and visual cortex. Using live imaging, genetics, and in silico modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.

Original languageEnglish
Pages (from-to)2466-2478
Number of pages13
JournalCurrent Biology
Volume25
Issue number19
DOIs
Publication statusPublished - 5 Oct 2015
Externally publishedYes

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