TY - JOUR
T1 - Migration speed of Cajal-Retzius cells modulated by vesicular trafficking controls the size of higher-order cortical areas
AU - Barber, Melissa
AU - Arai, Yoko
AU - Morishita, Yoshihiro
AU - Vigier, Lisa
AU - Causeret, Frédéric
AU - Borello, Ugo
AU - Ledonne, Fanny
AU - Coppola, Eva
AU - Contremoulins, Vincent
AU - Pfrieger, Frank W.
AU - Tissir, Fadel
AU - Govindan, Subashika
AU - Jabaudon, Denis
AU - Proux-Gillardeaux, Véronique
AU - Galli, Thierry
AU - Pierani, Alessandra
N1 - Publisher Copyright:
© 2015 Elsevier Ltd All rights reserved.
PY - 2015/10/5
Y1 - 2015/10/5
N2 - In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory, and visual cortex. Using live imaging, genetics, and in silico modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.
AB - In the neocortex, higher-order areas are essential to integrate sensory-motor information and have expanded in size during evolution. How higher-order areas are specified, however, remains largely unknown. Here, we show that the migration and distribution of early-born neurons, the Cajal-Retzius cells (CRs), controls the size of higher-order areas in the mouse somatosensory, auditory, and visual cortex. Using live imaging, genetics, and in silico modeling, we show that subtype-specific differences in the onset, speed, and directionality of CR migration determine their differential invasion of the developing cortical surface. CR migration speed is cell autonomously modulated by vesicle-associated membrane protein 3 (VAMP3), a classically non-neuronal mediator of endosomal recycling. Increasing CR migration speed alters their distribution in the developing cerebral cortex and leads to an expansion of postnatal higher-order areas and congruent rewiring of thalamo-cortical input. Our findings thus identify novel roles for neuronal migration and VAMP3-dependent vesicular trafficking in cortical wiring.
UR - http://www.scopus.com/inward/record.url?scp=84943449591&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2015.08.028
DO - 10.1016/j.cub.2015.08.028
M3 - Article
C2 - 26387718
AN - SCOPUS:84943449591
SN - 0960-9822
VL - 25
SP - 2466
EP - 2478
JO - Current Biology
JF - Current Biology
IS - 19
ER -