TY - JOUR
T1 - MiR-302d Competitively Binding with the lncRNA-341 Targets TLE4 in the Process of SSC Generation
AU - Zhang, Yani
AU - Zhang, Wenhui
AU - Hu, Cai
AU - Wang, Yingjie
AU - Wang, Man
AU - Zuo, Qisheng
AU - Elsayed, Ahmed Kamel
AU - Li, Yi
AU - Li, Bichun
N1 - Publisher Copyright:
© 2021 Yani Zhang et al.
PY - 2021
Y1 - 2021
N2 - MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.
AB - MicroRNAs (miRNAs) are essential factors in the reproductive process of poultry. Here, we found miR-302d is a potential differentiation and negative factor of chicken embryonic stem cells (ESCs) into spermatogonia stem cells (SSCs). The competition mechanism was carried out for the preliminary exploration to determine the relationship among miR-302d, lncRNA-341(interacting with miR-302d), and target gene TLE4. The results showed that lncRNA-341 can competitively bind to miR-302d to decrease the targeted binding of miR-302d and TLE4 which promotes the differentiation of chicken SSCs. Moreover, it is suggested that miR-302d may participate in the Wnt signaling pathway through TLE4.
UR - http://www.scopus.com/inward/record.url?scp=85108422363&partnerID=8YFLogxK
U2 - 10.1155/2021/5546936
DO - 10.1155/2021/5546936
M3 - Article
AN - SCOPUS:85108422363
SN - 1687-966X
VL - 2021
JO - Stem Cells International
JF - Stem Cells International
M1 - 5546936
ER -