Multipathways human health risk assessment of trihalomethane exposure through drinking water

Azhar Siddique; Sumayya Saied; Majid Mumtaz; Mirza M. Hussain; Haider A. Khwaja

doi:10.1016/j.ecoenv.2015.03.011

Multipathways human health risk assessment of trihalomethane exposure through drinking water

Azhar Siddique^*, Sumayya Saied, Majid Mumtaz, Mirza M. Hussain, Haider A. Khwaja

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Life-time human health risk of cancer attributed to trihalomethanes in drinking water in an urban-industrialized area of Karachi (Pakistan) was conducted through multiple pathways of exposure. The extent of cancer risk was compared with USEPA guidelines. Human health cancer risk for total trihalomethanes (TTHMs) through ingestion and dermal routes were estimated in "acceptable-low risk" (≥1.0E-06; ≤5.10E-05), whereas through inhalation route it was estimated under "acceptable-high risk" (≥5.10E-05; ≤1.0E-04) category. However, at some industrial-urban areas cancer risk for CHCl₃ were estimated under "unacceptable risk" (≥1.0E-04) through inhalation route.

Original language	English
Pages (from-to)	129-136
Number of pages	8
Journal	Ecotoxicology and Environmental Safety
Volume	116
DOIs	https://doi.org/10.1016/j.ecoenv.2015.03.011
Publication status	Published - 1 Jun 2015
Externally published	Yes

Keywords

Chloroform
Disinfection byproducts
Public health
Risk assessment
Trihalomethanes

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10.1016/j.ecoenv.2015.03.011

Cite this

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title = "Multipathways human health risk assessment of trihalomethane exposure through drinking water",

abstract = "Life-time human health risk of cancer attributed to trihalomethanes in drinking water in an urban-industrialized area of Karachi (Pakistan) was conducted through multiple pathways of exposure. The extent of cancer risk was compared with USEPA guidelines. Human health cancer risk for total trihalomethanes (TTHMs) through ingestion and dermal routes were estimated in {"}acceptable-low risk{"} (≥1.0E-06; ≤5.10E-05), whereas through inhalation route it was estimated under {"}acceptable-high risk{"} (≥5.10E-05; ≤1.0E-04) category. However, at some industrial-urban areas cancer risk for CHCl3 were estimated under {"}unacceptable risk{"} (≥1.0E-04) through inhalation route.",

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author = "Azhar Siddique and Sumayya Saied and Majid Mumtaz and Hussain, {Mirza M.} and Khwaja, {Haider A.}",

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T1 - Multipathways human health risk assessment of trihalomethane exposure through drinking water

AU - Siddique, Azhar

AU - Saied, Sumayya

AU - Mumtaz, Majid

AU - Hussain, Mirza M.

AU - Khwaja, Haider A.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Life-time human health risk of cancer attributed to trihalomethanes in drinking water in an urban-industrialized area of Karachi (Pakistan) was conducted through multiple pathways of exposure. The extent of cancer risk was compared with USEPA guidelines. Human health cancer risk for total trihalomethanes (TTHMs) through ingestion and dermal routes were estimated in "acceptable-low risk" (≥1.0E-06; ≤5.10E-05), whereas through inhalation route it was estimated under "acceptable-high risk" (≥5.10E-05; ≤1.0E-04) category. However, at some industrial-urban areas cancer risk for CHCl3 were estimated under "unacceptable risk" (≥1.0E-04) through inhalation route.

AB - Life-time human health risk of cancer attributed to trihalomethanes in drinking water in an urban-industrialized area of Karachi (Pakistan) was conducted through multiple pathways of exposure. The extent of cancer risk was compared with USEPA guidelines. Human health cancer risk for total trihalomethanes (TTHMs) through ingestion and dermal routes were estimated in "acceptable-low risk" (≥1.0E-06; ≤5.10E-05), whereas through inhalation route it was estimated under "acceptable-high risk" (≥5.10E-05; ≤1.0E-04) category. However, at some industrial-urban areas cancer risk for CHCl3 were estimated under "unacceptable risk" (≥1.0E-04) through inhalation route.

KW - Chloroform

KW - Disinfection byproducts

KW - Public health

KW - Risk assessment

KW - Trihalomethanes

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JO - Ecotoxicology and Environmental Safety

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ER -

Multipathways human health risk assessment of trihalomethane exposure through drinking water

Abstract

Keywords

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