TY - JOUR
T1 - N(2)-substituted D,L-cycloserine derivatives
T2 - Synthesis and evaluation as alanine racemase inhibitors
AU - Kim, Myoung Goo
AU - Strych, Ulrich
AU - Krause, Kurt
AU - Benedik, Michael
AU - Kohn, Harold
PY - 2003/2/1
Y1 - 2003/2/1
N2 - A select series of N(2)-substituted D,L-Cycloserine derivatives were prepared and evaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.
AB - A select series of N(2)-substituted D,L-Cycloserine derivatives were prepared and evaluated for inhibitory activity against purified alanine racemases (alr gene product) from Escherichia coli, Staphylococcus aureus, and Mycobacterium tuberculosis, as well as in a growth inhibition assay. N(2)-Modification led to loss of enzymatic inhibitory activity in most cases consistent with a recent proposal for cycloserine function.
UR - http://www.scopus.com/inward/record.url?scp=0345700229&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.56.160
DO - 10.7164/antibiotics.56.160
M3 - Article
C2 - 12715876
AN - SCOPUS:0345700229
SN - 0021-8820
VL - 56
SP - 160
EP - 168
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 2
ER -