Nb4C3Tx (MXene)/Au/DNA Aptasensor for the Ultraselective Electrochemical Detection of Lead in Water Samples

P. Abdul Rasheed; Ravi P. Pandey; Khadeeja A. Jabbar; Khaled A. Mahmoud

doi:10.1002/elan.202100685

Nb₄C₃T_x (MXene)/Au/DNA Aptasensor for the Ultraselective Electrochemical Detection of Lead in Water Samples

P. Abdul Rasheed^*, Ravi P. Pandey, Khadeeja A. Jabbar, Khaled A. Mahmoud^*

^*Corresponding author for this work

QEERI - Environment & Sustainability Center

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

An electrochemical aptasensor was designed for the ultraselective and sensitive detection of Pb²⁺ by using lead-specific binding DNA oligonucleotide as the molecular recognition element on Au nanoparticles/Nb₄C₃T_x MXene (Au@Nb₄C₃T_x) modified electrode. The Au@Nb₄C₃T_x is conjugated with thiol-modified lead-binding DNA through the Au−S bond. The DNA−Au@Nb₄C₃T_x modified glassy carbon electrode exhibited ultrahigh selectivity and enhanced response towards the detection of Pb²⁺ with a detection limit of 4 nM and linear range of 10 nM to 5 μM. This work has proved the possibility of using Nb₄C₃T_x as a robust immobilization platform for DNA oligonucleotides towards different environmental sensing and biomedical applications.

Original language	English
Pages (from-to)	1540-1546
Number of pages	7
Journal	Electroanalysis
Volume	34
Issue number	10
DOIs	https://doi.org/10.1002/elan.202100685
Publication status	Published - Oct 2022

Keywords

AuNPs
DNA oligonucleotide
NbCT MXene
Pb detection
electrochemical DNA sensor
nanocomposite

Access to Document

10.1002/elan.202100685

Cite this

@article{6f6aa0186b49493b954a4dc4e0077d75,

title = "Nb4C3Tx (MXene)/Au/DNA Aptasensor for the Ultraselective Electrochemical Detection of Lead in Water Samples",

abstract = "An electrochemical aptasensor was designed for the ultraselective and sensitive detection of Pb2+ by using lead-specific binding DNA oligonucleotide as the molecular recognition element on Au nanoparticles/Nb4C3Tx MXene (Au@Nb4C3Tx) modified electrode. The Au@Nb4C3Tx is conjugated with thiol-modified lead-binding DNA through the Au−S bond. The DNA−Au@Nb4C3Tx modified glassy carbon electrode exhibited ultrahigh selectivity and enhanced response towards the detection of Pb2+ with a detection limit of 4 nM and linear range of 10 nM to 5 μM. This work has proved the possibility of using Nb4C3Tx as a robust immobilization platform for DNA oligonucleotides towards different environmental sensing and biomedical applications.",

keywords = "AuNPs, DNA oligonucleotide, NbCT MXene, Pb detection, electrochemical DNA sensor, nanocomposite",

author = "Rasheed, {P. Abdul} and Pandey, {Ravi P.} and Jabbar, {Khadeeja A.} and Mahmoud, {Khaled A.}",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

year = "2022",

month = oct,

doi = "10.1002/elan.202100685",

language = "English",

volume = "34",

pages = "1540--1546",

journal = "Electroanalysis",

issn = "1040-0397",

publisher = "Wiley-VCH Verlag",

number = "10",

}

TY - JOUR

T1 - Nb4C3Tx (MXene)/Au/DNA Aptasensor for the Ultraselective Electrochemical Detection of Lead in Water Samples

AU - Rasheed, P. Abdul

AU - Pandey, Ravi P.

AU - Jabbar, Khadeeja A.

AU - Mahmoud, Khaled A.

PY - 2022/10

Y1 - 2022/10

N2 - An electrochemical aptasensor was designed for the ultraselective and sensitive detection of Pb2+ by using lead-specific binding DNA oligonucleotide as the molecular recognition element on Au nanoparticles/Nb4C3Tx MXene (Au@Nb4C3Tx) modified electrode. The Au@Nb4C3Tx is conjugated with thiol-modified lead-binding DNA through the Au−S bond. The DNA−Au@Nb4C3Tx modified glassy carbon electrode exhibited ultrahigh selectivity and enhanced response towards the detection of Pb2+ with a detection limit of 4 nM and linear range of 10 nM to 5 μM. This work has proved the possibility of using Nb4C3Tx as a robust immobilization platform for DNA oligonucleotides towards different environmental sensing and biomedical applications.

AB - An electrochemical aptasensor was designed for the ultraselective and sensitive detection of Pb2+ by using lead-specific binding DNA oligonucleotide as the molecular recognition element on Au nanoparticles/Nb4C3Tx MXene (Au@Nb4C3Tx) modified electrode. The Au@Nb4C3Tx is conjugated with thiol-modified lead-binding DNA through the Au−S bond. The DNA−Au@Nb4C3Tx modified glassy carbon electrode exhibited ultrahigh selectivity and enhanced response towards the detection of Pb2+ with a detection limit of 4 nM and linear range of 10 nM to 5 μM. This work has proved the possibility of using Nb4C3Tx as a robust immobilization platform for DNA oligonucleotides towards different environmental sensing and biomedical applications.

KW - AuNPs

KW - DNA oligonucleotide

KW - NbCT MXene

KW - Pb detection

KW - electrochemical DNA sensor

KW - nanocomposite

UR - http://www.scopus.com/inward/record.url?scp=85128042486&partnerID=8YFLogxK

U2 - 10.1002/elan.202100685

DO - 10.1002/elan.202100685

M3 - Article

AN - SCOPUS:85128042486

SN - 1040-0397

VL - 34

SP - 1540

EP - 1546

JO - Electroanalysis

JF - Electroanalysis

IS - 10

ER -

Nb₄C₃T_x (MXene)/Au/DNA Aptasensor for the Ultraselective Electrochemical Detection of Lead in Water Samples

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this