Near-infrared spectroscopy can detect differences in vascular responsiveness to a hyperglycaemic challenge in individuals with obesity compared to normal-weight individuals

Rogério Nogueira Soares, Raylene A. Reimer, Zaid Alenezi, Patricia K. Doyle-Baker, Juan Manuel Murias*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Objective: To examine whether the near-infrared spectroscopy combined with vascular occlusion test technique could detect differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity. Methods: A total of 16 normal-weight individuals (body mass index, 21.3 ± 1.7 kg/m2) and 13 individuals with obesity (body mass index, 34.4 ± 2.0 kg/m2) were submitted to five vascular occlusion tests (Pre, 30, 60, 90 and 120 min after glucose challenge). Vascular responsiveness was determined by the Slope 2 (Slope 2 StO2) and the area under the curve (StO2AUC) of oxygen saturation derived from near-infrared spectroscopy–vascular occlusion test. Results: The Slope 2 StO2 increased from 1.07 ± 0.16%/s (Pre) to 1.53 ± 0.21%/s at 90 min (p < 0.05) in the control group, while in obese it increased from 0.71 ± 0.09%/s (Pre) to 0.92 ± 0.14%/s at 60 min (p < 0.05), and to 0.97 ± 0.10%/s (p < 0.01) at 120 min after glucose ingestion. The StO2AUC decreased from 1729 ± 214%. sec (Pre) to 1259 ± 232%. sec at 60 min (p < 0.05) and to 1034 ± 172%. sec at 90 min (p < 0.05) in the normal-weight group, whereas it decreased at 90 min (637 ± 98%. sec; p < 0.05) and at 120 min (590 ± 93%. sec; p < 0.01) compared to 30 min (1232 ± 197%. sec) after glucose ingestion in individuals with obesity. Conclusion: Near-infrared spectroscopy–vascular occlusion test technique was capable of detecting differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity.

Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalDiabetes and Vascular Disease Research
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Keywords

  • Near-infrared spectroscopy
  • hyperglycaemia
  • obesity
  • vascular responsiveness

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