TY - JOUR
T1 - Near-infrared spectroscopy can detect differences in vascular responsiveness to a hyperglycaemic challenge in individuals with obesity compared to normal-weight individuals
AU - Soares, Rogério Nogueira
AU - Reimer, Raylene A.
AU - Alenezi, Zaid
AU - Doyle-Baker, Patricia K.
AU - Murias, Juan Manuel
N1 - Publisher Copyright:
© 2017, © The Author(s) 2017.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: To examine whether the near-infrared spectroscopy combined with vascular occlusion test technique could detect differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity. Methods: A total of 16 normal-weight individuals (body mass index, 21.3 ± 1.7 kg/m2) and 13 individuals with obesity (body mass index, 34.4 ± 2.0 kg/m2) were submitted to five vascular occlusion tests (Pre, 30, 60, 90 and 120 min after glucose challenge). Vascular responsiveness was determined by the Slope 2 (Slope 2 StO2) and the area under the curve (StO2AUC) of oxygen saturation derived from near-infrared spectroscopy–vascular occlusion test. Results: The Slope 2 StO2 increased from 1.07 ± 0.16%/s (Pre) to 1.53 ± 0.21%/s at 90 min (p < 0.05) in the control group, while in obese it increased from 0.71 ± 0.09%/s (Pre) to 0.92 ± 0.14%/s at 60 min (p < 0.05), and to 0.97 ± 0.10%/s (p < 0.01) at 120 min after glucose ingestion. The StO2AUC decreased from 1729 ± 214%. sec (Pre) to 1259 ± 232%. sec at 60 min (p < 0.05) and to 1034 ± 172%. sec at 90 min (p < 0.05) in the normal-weight group, whereas it decreased at 90 min (637 ± 98%. sec; p < 0.05) and at 120 min (590 ± 93%. sec; p < 0.01) compared to 30 min (1232 ± 197%. sec) after glucose ingestion in individuals with obesity. Conclusion: Near-infrared spectroscopy–vascular occlusion test technique was capable of detecting differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity.
AB - Objective: To examine whether the near-infrared spectroscopy combined with vascular occlusion test technique could detect differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity. Methods: A total of 16 normal-weight individuals (body mass index, 21.3 ± 1.7 kg/m2) and 13 individuals with obesity (body mass index, 34.4 ± 2.0 kg/m2) were submitted to five vascular occlusion tests (Pre, 30, 60, 90 and 120 min after glucose challenge). Vascular responsiveness was determined by the Slope 2 (Slope 2 StO2) and the area under the curve (StO2AUC) of oxygen saturation derived from near-infrared spectroscopy–vascular occlusion test. Results: The Slope 2 StO2 increased from 1.07 ± 0.16%/s (Pre) to 1.53 ± 0.21%/s at 90 min (p < 0.05) in the control group, while in obese it increased from 0.71 ± 0.09%/s (Pre) to 0.92 ± 0.14%/s at 60 min (p < 0.05), and to 0.97 ± 0.10%/s (p < 0.01) at 120 min after glucose ingestion. The StO2AUC decreased from 1729 ± 214%. sec (Pre) to 1259 ± 232%. sec at 60 min (p < 0.05) and to 1034 ± 172%. sec at 90 min (p < 0.05) in the normal-weight group, whereas it decreased at 90 min (637 ± 98%. sec; p < 0.05) and at 120 min (590 ± 93%. sec; p < 0.01) compared to 30 min (1232 ± 197%. sec) after glucose ingestion in individuals with obesity. Conclusion: Near-infrared spectroscopy–vascular occlusion test technique was capable of detecting differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity.
KW - Near-infrared spectroscopy
KW - hyperglycaemia
KW - obesity
KW - vascular responsiveness
UR - http://www.scopus.com/inward/record.url?scp=85038584600&partnerID=8YFLogxK
U2 - 10.1177/1479164117731481
DO - 10.1177/1479164117731481
M3 - Article
C2 - 28931323
AN - SCOPUS:85038584600
SN - 1479-1641
VL - 15
SP - 55
EP - 63
JO - Diabetes and Vascular Disease Research
JF - Diabetes and Vascular Disease Research
IS - 1
ER -