TY - JOUR
T1 - Near-infrared spectroscopy detects transient decrements and recovery of microvascular responsiveness following prolonged forearm ischemia
AU - Soares, Rogerio N.
AU - Somani, Yasina B.
AU - Al-Qahtani, Ahmad M.
AU - Proctor, David N.
AU - Murias, Juan M.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/9
Y1 - 2019/9
N2 - Background: Impairments at the microvascular level might lead to more overt cardiovascular complications, therefore, being able to early detect microvascular dysfunction would be beneficial. Thus, the present study investigated whether near-infrared spectroscopy (NIRS)assessment of microvascular responsiveness (reoxygenation slope, %.s−1)would detect the detrimental effects on the forearm microvasculature following a period of arterial occlusion. Similarly, the effects of prolonged forearm ischemia on brachial artery function were also assessed by flow-mediated dilation (%FMD). Methods: Fourteen individuals were tested before (Pre), immediately after (PostPI), 30 min after (Post30), and 60 min after (Post60)prolonged forearm ischemia. The Pre, Post30, and Post60 interventions consisted of 5 min of blood flow occlusion, whereas the postPI involved a 20-min occlusion period. Results: The reoxygenation slope was reduced at PostPI (1.33 ± 0.72%.s−1 vs. 1.79 ± 0.68%.s−1 Pre; p < 0.05), but not at Post30 (1.93 ± 0.70%.s−1)and Post60 (1.87 ± 0.85%.s−1)(both p > 0.05 vs. Pre). Similarly, the brachial FMD response was reduced at PostPI (7.4 ± 3.9% vs. 10.9 ± 2.9% Pre; p < 0.05), but not at Post30 (11.3 ± 4.1%)or Post60 (11.8 ± 4.3%)(both p > 0.05 vs. Pre). Conclusion: These findings show that NIRS-derived reoxygenation slope detects the transient detrimental effects of prolonged ischemia within the forearm microvasculature. Additionally, this study found that the reduction in forearm microvascular responsiveness might have contributed to the decreased brachial artery FMD responsiveness.
AB - Background: Impairments at the microvascular level might lead to more overt cardiovascular complications, therefore, being able to early detect microvascular dysfunction would be beneficial. Thus, the present study investigated whether near-infrared spectroscopy (NIRS)assessment of microvascular responsiveness (reoxygenation slope, %.s−1)would detect the detrimental effects on the forearm microvasculature following a period of arterial occlusion. Similarly, the effects of prolonged forearm ischemia on brachial artery function were also assessed by flow-mediated dilation (%FMD). Methods: Fourteen individuals were tested before (Pre), immediately after (PostPI), 30 min after (Post30), and 60 min after (Post60)prolonged forearm ischemia. The Pre, Post30, and Post60 interventions consisted of 5 min of blood flow occlusion, whereas the postPI involved a 20-min occlusion period. Results: The reoxygenation slope was reduced at PostPI (1.33 ± 0.72%.s−1 vs. 1.79 ± 0.68%.s−1 Pre; p < 0.05), but not at Post30 (1.93 ± 0.70%.s−1)and Post60 (1.87 ± 0.85%.s−1)(both p > 0.05 vs. Pre). Similarly, the brachial FMD response was reduced at PostPI (7.4 ± 3.9% vs. 10.9 ± 2.9% Pre; p < 0.05), but not at Post30 (11.3 ± 4.1%)or Post60 (11.8 ± 4.3%)(both p > 0.05 vs. Pre). Conclusion: These findings show that NIRS-derived reoxygenation slope detects the transient detrimental effects of prolonged ischemia within the forearm microvasculature. Additionally, this study found that the reduction in forearm microvascular responsiveness might have contributed to the decreased brachial artery FMD responsiveness.
KW - FMD
KW - Microcirculation
KW - Microvascular dysfunction
KW - NIRS
UR - http://www.scopus.com/inward/record.url?scp=85065525940&partnerID=8YFLogxK
U2 - 10.1016/j.mvr.2019.04.009
DO - 10.1016/j.mvr.2019.04.009
M3 - Article
C2 - 31047890
AN - SCOPUS:85065525940
SN - 0026-2862
VL - 125
JO - Microvascular Research
JF - Microvascular Research
M1 - 103879
ER -