No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

Dirk Goossens; Sandra Villafuerte; Fadel Tissir; Sofie Van Gestel; Stephan Claes; Daniel Souery; Isabelle Massat; Dirk Van Den Bossche; Karel Van Zand; Julien Mendlewicz; Christine Van Broeckhoven; Jurgen Del-Favero

doi:10.1038/sj.ejhg.5200469

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

Dirk Goossens, Sandra Villafuerte, Fadel Tissir, Sofie Van Gestel, Stephan Claes, Daniel Souery, Isabelle Massat, Dirk Van Den Bossche, Karel Van Zand, Julien Mendlewicz, Christine Van Broeckhoven, Jurgen Del-Favero^*

^*Corresponding author for this work

Biological and Biomedical Sciences

University of Antwerp

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	European Journal of Human Genetics
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/sj.ejhg.5200469
Publication status	Published - May 2000

Keywords

Bipolar disorder
CAG/CTG
Chromosome 18
Trinucleotide repeat
YAC fragmentation

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10.1038/sj.ejhg.5200469

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Goossens, D., Villafuerte, S., Tissir, F., Van Gestel, S., Claes, S., Souery, D., Massat, I., Van Den Bossche, D., Van Zand, K., Mendlewicz, J., Van Broeckhoven, C., & Del-Favero, J. (2000). No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder. European Journal of Human Genetics, 8(5), 385-388. https://doi.org/10.1038/sj.ejhg.5200469

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title = "No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder",

abstract = "We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.",

keywords = "Bipolar disorder, CAG/CTG, Chromosome 18, Trinucleotide repeat, YAC fragmentation",

author = "Dirk Goossens and Sandra Villafuerte and Fadel Tissir and {Van Gestel}, Sofie and Stephan Claes and Daniel Souery and Isabelle Massat and {Van Den Bossche}, Dirk and {Van Zand}, Karel and Julien Mendlewicz and {Van Broeckhoven}, Christine and Jurgen Del-Favero",

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Goossens, D, Villafuerte, S, Tissir, F, Van Gestel, S, Claes, S, Souery, D, Massat, I, Van Den Bossche, D, Van Zand, K, Mendlewicz, J, Van Broeckhoven, C & Del-Favero, J 2000, 'No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder', European Journal of Human Genetics, vol. 8, no. 5, pp. 385-388. https://doi.org/10.1038/sj.ejhg.5200469

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T1 - No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

AU - Goossens, Dirk

AU - Villafuerte, Sandra

AU - Tissir, Fadel

AU - Van Gestel, Sofie

AU - Claes, Stephan

AU - Souery, Daniel

AU - Massat, Isabelle

AU - Van Den Bossche, Dirk

AU - Van Zand, Karel

AU - Mendlewicz, Julien

AU - Van Broeckhoven, Christine

AU - Del-Favero, Jurgen

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N2 - We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

AB - We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

KW - Bipolar disorder

KW - CAG/CTG

KW - Chromosome 18

KW - Trinucleotide repeat

KW - YAC fragmentation

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JO - European Journal of Human Genetics

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ER -

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

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