Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

Muhammad Anwar, Andrew R. Cowley, Mark G. Moloney

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.

Original languageEnglish
Pages (from-to)1758-1770
Number of pages13
JournalTetrahedron Asymmetry
Volume21
Issue number13-14
DOIs
Publication statusPublished - 2010
Externally publishedYes

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