Abstract
The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.
Original language | English |
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Pages (from-to) | 1758-1770 |
Number of pages | 13 |
Journal | Tetrahedron Asymmetry |
Volume | 21 |
Issue number | 13-14 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |