Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses

Cunzheng Li; Ji an Wei; Diyang Wang; Zhihua Luo; Chaoqin Pang; Kai Chen; Juan Duan; Bailing Chen; Libing Zhou; Fadel Tissir; Lei Shi; Kwok Fai So; Li Zhang; Yibo Qu

doi:10.1016/j.pneurobio.2022.102352

Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses

Cunzheng Li, Ji an Wei, Diyang Wang, Zhihua Luo, Chaoqin Pang, Kai Chen, Juan Duan, Bailing Chen, Libing Zhou, Fadel Tissir, Lei Shi, Kwok Fai So, Li Zhang^*, Yibo Qu

^*Corresponding author for this work

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A few developmental genes remain persistently expressed in the adult stage, whilst their potential functions in the mature brain remain underappreciated. Here, we report the unexpected importance of Celsr2, a core Planar cell polarity (PCP) component, in maintaining the structural and functional integrity of adult neocortex. Celsr2 is highly expressed during development and remains expressed in adult neocortex. In vivo synaptic imaging in Celsr2 deficient mice revealed alterations in spinogenesis and reduced neuronal calcium activities, which are associated with impaired motor learning. These phenotypes were accompanied with anomalies of both postsynaptic organization and presynaptic vesicles. Knockout of Celsr2 in adult mice recapitulated those features, further supporting the role of Celsr2 in maintaining the integrity of mature cortex. In sum, our data identify previously unrecognized roles of Celsr2 in the maintenance of synaptic function and motor learning in adulthood.

Original language	English
Article number	102352
Number of pages	14
Journal	Progress in Neurobiology
Volume	219
DOIs	https://doi.org/10.1016/j.pneurobio.2022.102352
Publication status	Published - Dec 2022

Keywords

Corticostriatal circuit
De novo spinogenesis
Motor learning
Pla2g4e
Synaptic plasticity

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10.1016/j.pneurobio.2022.102352

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title = "Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses",

abstract = "A few developmental genes remain persistently expressed in the adult stage, whilst their potential functions in the mature brain remain underappreciated. Here, we report the unexpected importance of Celsr2, a core Planar cell polarity (PCP) component, in maintaining the structural and functional integrity of adult neocortex. Celsr2 is highly expressed during development and remains expressed in adult neocortex. In vivo synaptic imaging in Celsr2 deficient mice revealed alterations in spinogenesis and reduced neuronal calcium activities, which are associated with impaired motor learning. These phenotypes were accompanied with anomalies of both postsynaptic organization and presynaptic vesicles. Knockout of Celsr2 in adult mice recapitulated those features, further supporting the role of Celsr2 in maintaining the integrity of mature cortex. In sum, our data identify previously unrecognized roles of Celsr2 in the maintenance of synaptic function and motor learning in adulthood.",

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author = "Cunzheng Li and Wei, {Ji an} and Diyang Wang and Zhihua Luo and Chaoqin Pang and Kai Chen and Juan Duan and Bailing Chen and Libing Zhou and Fadel Tissir and Lei Shi and So, {Kwok Fai} and Li Zhang and Yibo Qu",

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year = "2022",

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doi = "10.1016/j.pneurobio.2022.102352",

language = "English",

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T1 - Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses

AU - Li, Cunzheng

AU - Wei, Ji an

AU - Wang, Diyang

AU - Luo, Zhihua

AU - Pang, Chaoqin

AU - Chen, Kai

AU - Duan, Juan

AU - Chen, Bailing

AU - Zhou, Libing

AU - Tissir, Fadel

AU - Shi, Lei

AU - So, Kwok Fai

AU - Zhang, Li

AU - Qu, Yibo

PY - 2022/12

Y1 - 2022/12

N2 - A few developmental genes remain persistently expressed in the adult stage, whilst their potential functions in the mature brain remain underappreciated. Here, we report the unexpected importance of Celsr2, a core Planar cell polarity (PCP) component, in maintaining the structural and functional integrity of adult neocortex. Celsr2 is highly expressed during development and remains expressed in adult neocortex. In vivo synaptic imaging in Celsr2 deficient mice revealed alterations in spinogenesis and reduced neuronal calcium activities, which are associated with impaired motor learning. These phenotypes were accompanied with anomalies of both postsynaptic organization and presynaptic vesicles. Knockout of Celsr2 in adult mice recapitulated those features, further supporting the role of Celsr2 in maintaining the integrity of mature cortex. In sum, our data identify previously unrecognized roles of Celsr2 in the maintenance of synaptic function and motor learning in adulthood.

AB - A few developmental genes remain persistently expressed in the adult stage, whilst their potential functions in the mature brain remain underappreciated. Here, we report the unexpected importance of Celsr2, a core Planar cell polarity (PCP) component, in maintaining the structural and functional integrity of adult neocortex. Celsr2 is highly expressed during development and remains expressed in adult neocortex. In vivo synaptic imaging in Celsr2 deficient mice revealed alterations in spinogenesis and reduced neuronal calcium activities, which are associated with impaired motor learning. These phenotypes were accompanied with anomalies of both postsynaptic organization and presynaptic vesicles. Knockout of Celsr2 in adult mice recapitulated those features, further supporting the role of Celsr2 in maintaining the integrity of mature cortex. In sum, our data identify previously unrecognized roles of Celsr2 in the maintenance of synaptic function and motor learning in adulthood.

KW - Corticostriatal circuit

KW - De novo spinogenesis

KW - Motor learning

KW - Pla2g4e

KW - Synaptic plasticity

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U2 - 10.1016/j.pneurobio.2022.102352

DO - 10.1016/j.pneurobio.2022.102352

M3 - Article

C2 - 36089108

AN - SCOPUS:85138169091

SN - 0301-0082

VL - 219

JO - Progress in Neurobiology

JF - Progress in Neurobiology

M1 - 102352

ER -

Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses

Abstract

Keywords

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