TY - JOUR
T1 - Power-law dynamics in an auditory-nerve model can account for neural adaptation to sound-level statistics
AU - Zilany, Muhammad S.A.
AU - Carney, Laurel H.
PY - 2010/8/4
Y1 - 2010/8/4
N2 - Neurons in the auditory system respond to recent stimulus-level history by adapting their response functions according to the statistics of the stimulus, partially alleviating the so-called "dynamic-range problem." However, the mechanism and source of this adaptation along the auditory pathway remain unknown. Inclusion of power-law dynamics in a phenomenological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neural adaptation to sound-level statistics, including the time course of adaptation of the mean firing rate and changes in the dynamic range observed in AN responses. A direct comparison between model responses to a dynamic stimulus and to an "inversely gated" static background suggested that AN dynamic-range adaptation largely results from the adaptation produced by the response history. These results support the hypothesis that the potential mechanism underlying the dynamic-range adaptation observed at the level of the auditory nerve is located peripheral to the spike generation mechanism and central to the IHC receptor potential.
AB - Neurons in the auditory system respond to recent stimulus-level history by adapting their response functions according to the statistics of the stimulus, partially alleviating the so-called "dynamic-range problem." However, the mechanism and source of this adaptation along the auditory pathway remain unknown. Inclusion of power-law dynamics in a phenomenological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neural adaptation to sound-level statistics, including the time course of adaptation of the mean firing rate and changes in the dynamic range observed in AN responses. A direct comparison between model responses to a dynamic stimulus and to an "inversely gated" static background suggested that AN dynamic-range adaptation largely results from the adaptation produced by the response history. These results support the hypothesis that the potential mechanism underlying the dynamic-range adaptation observed at the level of the auditory nerve is located peripheral to the spike generation mechanism and central to the IHC receptor potential.
UR - http://www.scopus.com/inward/record.url?scp=77955388334&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.0647-10.2010
DO - 10.1523/JNEUROSCI.0647-10.2010
M3 - Article
C2 - 20685981
AN - SCOPUS:77955388334
SN - 0270-6474
VL - 30
SP - 10380
EP - 10390
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 31
ER -