Predicting Overall Survival in METABRIC Cohort Using Machine Learning

Afroz Banu, Rayyan Ahmed, Saleh Musleh, Zubair Shah, Mowafa Househ, Tanvir Alam*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that presents very high relapse and mortality. However, due to differences in the genetic architecture associated with TNBC, patients have different outcomes and respond differently to available treatments. In this study, we predicted the overall survival of TNBC patients in the METABRIC cohort employing supervised machine learning to identify important clinical and genetic features that are associated with better survival. We achieved a slightly higher Concordance index than the state of art and identified biological pathways related to the top genes considered important by our model.

Original languageEnglish
Title of host publicationHealthcare Transformation with Informatics and Artificial Intelligence
EditorsJohn Mantas, Parisis Gallos, Emmanouil Zoulias, Arie Hasman, Mowafa S. Househ, Martha Charalampidou, Andriana Magdalinou
PublisherIOS Press BV
Pages632-635
Number of pages4
ISBN (Electronic)9781643684000
DOIs
Publication statusPublished - 29 Jun 2023
Event21st International Conference on Informatics, Management, and Technology in Healthcare, ICIMTH 2023 - Athens, Greece
Duration: 1 Jul 20233 Jul 2023

Publication series

NameStudies in Health Technology and Informatics
Volume305
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Conference

Conference21st International Conference on Informatics, Management, and Technology in Healthcare, ICIMTH 2023
Country/TerritoryGreece
CityAthens
Period1/07/233/07/23

Keywords

  • Breast Cancer
  • Machine Learning

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