TY - JOUR
T1 - Prevalence of nephropathy in type 1 diabetes in the Arab world
T2 - A systematic review and meta-analysis
AU - Abdel-Motal, Ussama M.
AU - Akila, G.
AU - Abdelalim, Essam M.
AU - Ponnuraja, Chinnaiyan
AU - Iken, Khadija
AU - Jahromi, Mohamed
AU - Doss, George Priya
AU - El Bekay, Rajaa
AU - Zayed, Hatem
N1 - Publisher Copyright:
Copyright © 2018 John Wiley & Sons, Ltd.
PY - 2018/10
Y1 - 2018/10
N2 - The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D.
AB - The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different literature databases (PubMed, ScienceDirect, Web of Science, and Embase) to capture all relevant data about Arab patients with T1D that had DN. Meta-analysis and systematic review were performed using the random effect model, and the heterogeneity of the studies was assessed using the Q-test, I2, and Tau-squared statistics. Publication bias was assessed using the funnel-plot test. Our search strategy captured 372 studies in only 10 out of the 22 Arab countries in a period of 48 years (1969-2017); of which, 41 met our inclusion criteria for full article analysis, of those, 15 were eligible for meta-analysis. We estimated the prevalence of DN among Arab people with T1D to be 18.2% (95% confidence interval 13.1%-24.8%). In conclusion, DN prevalence is underexplored among Arab patients with T1D and represents a significant risk for the well-being of Arab patients with T1D. Therefore, there is an urgent need for comprehensive epidemiological studies for DN among Arab patients with T1D.
KW - Arab populations
KW - diabetic nephropathy
KW - kidney disease
KW - prevalence
KW - type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85054335101&partnerID=8YFLogxK
U2 - 10.1002/dmrr.3026
DO - 10.1002/dmrr.3026
M3 - Review article
C2 - 29774648
AN - SCOPUS:85054335101
SN - 1520-7552
VL - 34
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 7
M1 - e3026
ER -