TY - JOUR
T1 - Primary Small Cell Carcinoma of the Esophagus (PSCEC) Associated with Paraneoplastic Sweating Syndrome
T2 - A Case Report and Literature Review
AU - Masoum, Seyed Hosein Fattahi
AU - Sharifi, Noorieh
AU - Jamshidi, Shirin Taraz
AU - Sharifian, Alireza
AU - Rezaee, Reza
N1 - Publisher Copyright:
© 2015 Mashhad University of Medical Sciences. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Introduction: Primary small cell carcinoma of the esophagus (PSCEC) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. The lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. So far more than 200 cases of PSCEC have been reported in literature. Case Report: The patient is a 54-year-old female from the Golestan province who presented with dysphagia, 19 kg-weight loss (from 105 kgs to 86 kgs), and excessive sweating. She was admitted in the thoracic surgery ward, at Ghaem Hospital, in the Mashhad University of Medical Sciences, with a pathological diagnosis of small cell carcinoma. She underwent transhiatal total esophagectomy. Excessive sweating was eradicated after surgery and she was discharged after 13 days without any complication. She received chemotherapy and at her 5-year follow up, she showed no recurrence or metastasis. Conclusion: PSCEC usually requires chemotherapy with or without surgery. A favorable outcome, with total resection of the lesion combined with chemotherapy, was obtained. However, due to the rarity of the disease there is no definitive choice of treatment.
AB - Introduction: Primary small cell carcinoma of the esophagus (PSCEC) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. The lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. So far more than 200 cases of PSCEC have been reported in literature. Case Report: The patient is a 54-year-old female from the Golestan province who presented with dysphagia, 19 kg-weight loss (from 105 kgs to 86 kgs), and excessive sweating. She was admitted in the thoracic surgery ward, at Ghaem Hospital, in the Mashhad University of Medical Sciences, with a pathological diagnosis of small cell carcinoma. She underwent transhiatal total esophagectomy. Excessive sweating was eradicated after surgery and she was discharged after 13 days without any complication. She received chemotherapy and at her 5-year follow up, she showed no recurrence or metastasis. Conclusion: PSCEC usually requires chemotherapy with or without surgery. A favorable outcome, with total resection of the lesion combined with chemotherapy, was obtained. However, due to the rarity of the disease there is no definitive choice of treatment.
KW - Chemotherapy
KW - Paraneoplastic syndrome
KW - Prognosis
KW - Small cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85009248961&partnerID=8YFLogxK
U2 - 10.22038/IJORL.2015.5475
DO - 10.22038/IJORL.2015.5475
M3 - Review article
AN - SCOPUS:85009248961
SN - 2251-7251
VL - 27
SP - 473
EP - 477
JO - Iranian Journal of Otorhinolaryngology
JF - Iranian Journal of Otorhinolaryngology
IS - 6
ER -