Quantitative analysis of rate-dependent of human heart failure action potential model on alternans onset and arrhythmias

It is known that at the living organism level, heart failure (HF) increases the susceptibility to and incidence of cardiac alternans, both of which are strongly associated with sudden cardiac death (SCD). We use mathematical models to investigate how electrophysiological properties consistent with heart failure affect the onset and magnitude of electrical alternans and its mechanism compared to similar cases in normal human cells. We study how APD restitution curves and short-term memory are altered in normal and HF-affected cells and tissue. We compare our results with available experimental observations and find good agreement.