Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines

Sandhanasamy Devanesan; Mohamad S. AlSalhi; Radhakrishnan Vishnubalaji; Akram A. Alfuraydi; Nehad M. Alajez; Musaad Alfayez; Kadarkarai Murugan; Shaban R.M. Sayed; Marcello Nicoletti; Giovanni Benelli

doi:10.1007/s10876-016-1134-4

Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines

Sandhanasamy Devanesan, Mohamad S. AlSalhi^*, Radhakrishnan Vishnubalaji, Akram A. Alfuraydi, Nehad M. Alajez, Musaad Alfayez, Kadarkarai Murugan, Shaban R.M. Sayed, Marcello Nicoletti, Giovanni Benelli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

In this research we focused on the green synthesis of silver nanoparticles (AgNPs) using Pimpinella anisum seed extract. Furthermore, we evaluated their cytotoxicity on colorectal cancer (CRC) cell lines. Our results revealed the anti-cancerous cytotoxic potential of green synthesized AgNPs. Green synthesized AgNPs exhibited high cytotoxicity on colorectal adenocarcinoma CRC cells. They selectively killed cancer cells through suppression of proliferation, cell cycle arrest at the G2/M phase, and induction of apoptosis. Interestingly, between the two different clones, SW620 cells were more sensitive than HCT8 cells. Overall, our findings suggest that AgNPs could be effective cancer chemotherapeutic agents or a combination nano-drug in future anti-cancer therapy.

Original language	English
Pages (from-to)	595-605
Number of pages	11
Journal	Journal of Cluster Science
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/s10876-016-1134-4
Publication status	Published - 1 Jan 2017
Externally published	Yes

Keywords

Colorectal cancer cell lines
Nano-drugs
Nanostructures
Optical properties

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10.1007/s10876-016-1134-4

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Devanesan, S., AlSalhi, M. S., Vishnubalaji, R., Alfuraydi, A. A., Alajez, N. M., Alfayez, M., Murugan, K., Sayed, S. R. M., Nicoletti, M., & Benelli, G. (2017). Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines. Journal of Cluster Science, 28(1), 595-605. https://doi.org/10.1007/s10876-016-1134-4

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title = "Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines",

abstract = "In this research we focused on the green synthesis of silver nanoparticles (AgNPs) using Pimpinella anisum seed extract. Furthermore, we evaluated their cytotoxicity on colorectal cancer (CRC) cell lines. Our results revealed the anti-cancerous cytotoxic potential of green synthesized AgNPs. Green synthesized AgNPs exhibited high cytotoxicity on colorectal adenocarcinoma CRC cells. They selectively killed cancer cells through suppression of proliferation, cell cycle arrest at the G2/M phase, and induction of apoptosis. Interestingly, between the two different clones, SW620 cells were more sensitive than HCT8 cells. Overall, our findings suggest that AgNPs could be effective cancer chemotherapeutic agents or a combination nano-drug in future anti-cancer therapy.",

keywords = "Colorectal cancer cell lines, Nano-drugs, Nanostructures, Optical properties",

author = "Sandhanasamy Devanesan and AlSalhi, {Mohamad S.} and Radhakrishnan Vishnubalaji and Alfuraydi, {Akram A.} and Alajez, {Nehad M.} and Musaad Alfayez and Kadarkarai Murugan and Sayed, {Shaban R.M.} and Marcello Nicoletti and Giovanni Benelli",

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doi = "10.1007/s10876-016-1134-4",

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Devanesan, S, AlSalhi, MS, Vishnubalaji, R, Alfuraydi, AA, Alajez, NM, Alfayez, M, Murugan, K, Sayed, SRM, Nicoletti, M & Benelli, G 2017, 'Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines', Journal of Cluster Science, vol. 28, no. 1, pp. 595-605. https://doi.org/10.1007/s10876-016-1134-4

TY - JOUR

T1 - Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines

AU - Devanesan, Sandhanasamy

AU - AlSalhi, Mohamad S.

AU - Vishnubalaji, Radhakrishnan

AU - Alfuraydi, Akram A.

AU - Alajez, Nehad M.

AU - Alfayez, Musaad

AU - Murugan, Kadarkarai

AU - Sayed, Shaban R.M.

AU - Nicoletti, Marcello

AU - Benelli, Giovanni

PY - 2017/1/1

Y1 - 2017/1/1

N2 - In this research we focused on the green synthesis of silver nanoparticles (AgNPs) using Pimpinella anisum seed extract. Furthermore, we evaluated their cytotoxicity on colorectal cancer (CRC) cell lines. Our results revealed the anti-cancerous cytotoxic potential of green synthesized AgNPs. Green synthesized AgNPs exhibited high cytotoxicity on colorectal adenocarcinoma CRC cells. They selectively killed cancer cells through suppression of proliferation, cell cycle arrest at the G2/M phase, and induction of apoptosis. Interestingly, between the two different clones, SW620 cells were more sensitive than HCT8 cells. Overall, our findings suggest that AgNPs could be effective cancer chemotherapeutic agents or a combination nano-drug in future anti-cancer therapy.

AB - In this research we focused on the green synthesis of silver nanoparticles (AgNPs) using Pimpinella anisum seed extract. Furthermore, we evaluated their cytotoxicity on colorectal cancer (CRC) cell lines. Our results revealed the anti-cancerous cytotoxic potential of green synthesized AgNPs. Green synthesized AgNPs exhibited high cytotoxicity on colorectal adenocarcinoma CRC cells. They selectively killed cancer cells through suppression of proliferation, cell cycle arrest at the G2/M phase, and induction of apoptosis. Interestingly, between the two different clones, SW620 cells were more sensitive than HCT8 cells. Overall, our findings suggest that AgNPs could be effective cancer chemotherapeutic agents or a combination nano-drug in future anti-cancer therapy.

KW - Colorectal cancer cell lines

KW - Nano-drugs

KW - Nanostructures

KW - Optical properties

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DO - 10.1007/s10876-016-1134-4

M3 - Article

AN - SCOPUS:85006724613

SN - 1040-7278

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SP - 595

EP - 605

JO - Journal of Cluster Science

JF - Journal of Cluster Science

IS - 1

ER -

Rapid Biological Synthesis of Silver Nanoparticles Using Plant Seed Extracts and Their Cytotoxicity on Colorectal Cancer Cell Lines

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